ArticleThe Journal of cell biology2001
A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed, 204 citations in OpenAlex.
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- Programmed cortical ER collapse drives selective ER degradation and inheritance in yeast meiosis.The Journal of cell biology · 2021Article
- A preferred sequence for organelle inheritance during polarized cell growth.Journal of cell science · 2021Article
- Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation.Molecular biology of the cell · 2021Article
- Cdc1p is a Golgi-localized glycosylphosphatidylinositol-anchored protein remodelase.Molecular biology of the cell · 2020Article
- MICOS subcomplexes assemble independently on the mitochondrial inner membrane in proximity to ER contact sites.The Journal of cell biology · 2020Article
- A photostable monomeric superfolder green fluorescent protein.Traffic (Copenhagen, Denmark) · 2020Article
- Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes.Nature communications · 2020Article
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- A conserved mechanism for mitochondria-dependent dynein anchoring.Molecular biology of the cell · 2019Article
- Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference.Immunologic research · 2019Review
- An improved secretion signal enhances the secretion of model proteins from Pichia pastoris.Microbial cell factories · 2018Article
- The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner.Nature communications · 2018Article
51 more citing papers are in PubMed but not listed here.
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7 authors at 1 institution in 1 country.
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Abstract
In Saccharomyces cerevisiae, Golgi elements are present in the bud very early in the cell cycle. We have analyzed this Golgi inheritance process using fluorescence microscopy and genetics. In rapidly growing cells, late Golgi elements show an actin-dependent concentration at sites of polarized growth. Late Golgi elements are apparently transported into the bud along actin cables and are also retained in the bud by a mechanism that may involve actin. A visual screen for mutants defective in the inheritance of late Golgi elements yielded multiple alleles of CDC1. Mutations in CDC1 severely depolarize the actin cytoskeleton, and these mutations prevent late Golgi elements from being retained in the bud. The efficient localization of late Golgi elements to the bud requires the type V myosin Myo2p, further suggesting that actin plays a role in Golgi inheritance. Surprisingly, early and late Golgi elements are inherited by different pathways, with early Golgi elements localizing to the bud in a Cdc1p- and Myo2p-independent manner. We propose that early Golgi elements arise from ER membranes that are present in the bud. These two pathways of Golgi inheritance in S. cerevisiae resemble Golgi inheritance pathways in vertebrate cells.
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