ArticleThe EMBO journal2001
Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 101 citations in OpenAlex.
- Indole-3-Carbinol and Its Derivatives as Neuroprotective Modulators.Brain sciences · 2024Review
- Neuronal Scaffold Protein ARMS Interacts with Synaptotagmin-4 C2AB through the Ankyrin Repeat Domain with an Unexpected Mode.International journal of molecular sciences · 2023Article
- Mechanisms Controlling the Expression and Secretion of BDNF.Biomolecules · 2023Review
- Coadministration of tianeptine alters behavioral parameters and levels of neurotrophins in a chronic model of Maple Syrup Urine disease.Metabolic brain disease · 2022Article
- Membrane lipid raft homeostasis is directly linked to neurodegeneration.Essays in biochemistry · 2021Review
- TrkB signaling contributes to transdiaphragmatic pressure generation in aged mice.Journal of neurophysiology · 2021Article
- The physiology of regulated BDNF release.Cell and tissue research · 2020Review
- Regulation of BDNF Release by ARMS/Kidins220 through Modulation of Synaptotagmin-IV Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Molecular neurobiology · 2017Review
- Neurobiology of local and intercellular BDNF signaling.Pflugers Archiv : European journal of physiology · 2017Review
- Glioactive ATP controls BDNF recycling in cortical astrocytes.Communicative & integrative biology · 2017Article
- Intracerebroventricular administration of α-ketoisocaproic acid decreases brain-derived neurotrophic factor and nerve growth factor levels in brain of young rats.Metabolic brain disease · 2016Article
- Role for Endogenous BDNF in Endocannabinoid-Mediated Long-Term Depression at Neocortical Inhibitory SynapseseNeuro · 2015Article
- High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons.Frontiers in cellular neuroscience · 2014Article
- Temporal decoding of MAP kinase and CREB phosphorylation by selective immediate early gene expression.PloS one · 2013Article
- Exogenous gangliosides increase the release of brain-derived neurotrophic factor.Neuropharmacology · 2011Article
- Role of neuronal ras activity in adult hippocampal neurogenesis and cognition.Frontiers in neuroscience · 2011Article
- Neocortical axon arbors trade-off material and conduction delay conservation.PLoS computational biology · 2010Article
- Exercise can rescue recognition memory impairment in a model with reduced adult hippocampal neurogenesis.Frontiers in behavioral neuroscience · 2010Article
- Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway.ASN neuro · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophins (NTs) play an essential role in modulating activity-dependent neuronal plasticity. In this context, the site and extent of NT secretion are of crucial importance. Here, we demonstrate that the activation of phospolipase C (PLC) and the subsequent mobilization of Ca(2+) from intracellular stores are essential for NT secretion initiated by both Trk and glutamate receptor activation. Mutational analysis of tyrosine residues, highly conserved in the cytoplasmic domain of all Trk receptors, revealed that the activation of PLC-gamma in cultured hippocampal neurons and nnr5 cells is necessary to mobilize Ca(2+) from intracellular stores, the key mechanism for regulated NT secretion. A similar signalling mechanism has been identified for glutamate-mediated NT secretion-which in part depends on the activation of PLC via metabotropic receptors-leading to the mobilization of Ca(2+) from internal stores by inositol trisphosphate. Thus, PLC-mediated signal transduction pathways are the common mechanisms for both Trk- and mGluRI-mediated NT secretion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.