ArticleThe EMBO journal2001
Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture.Journal of tissue engineering and regenerative medicine · 2013Trial
- ATM in immunobiology: From lymphocyte development to cancer immunotherapy.Translational oncology · 2025Review
- ATM directs DNA damage responses and proteostasis via genetically separable pathways.Science signaling · 2018Article
- Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction.Free radical biology & medicine · 2016Article
- Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.Physiological reviews · 2016Review
- Stem cells, redox signaling, and stem cell aging.Antioxidants & redox signaling · 2014Review
- Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- A bioinformatics filtering strategy for identifying radiation response biomarker candidates.PloS one · 2012Article
- Overexpression of SOD in retina: need for increase in H2O2-detoxifying enzyme in same cellular compartment.Free radical biology & medicine · 2011Article
- Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization.Molecular carcinogenesis · 2009Article
- Oxidative stress in the regulation of normal and neoplastic hematopoiesis.Antioxidants & redox signaling · 2008Review
- Review
- Modulation of oxidative stress in response to gamma-radiation in human glioma cell lines.Journal of neuro-oncology · 2003Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with the genetic disorder ataxia-telangiectasia (A-T) display a pleiotropic phenotype that includes neurodegeneration, immunodeficiency, cancer predisposition and hypersensitivity to ionizing radiation. The gene responsible is ATM, and ATM:-knockout mice recapitulate most features of A-T. In order to study the involvement of oxidative stress in the A-T phenotype, we examined mice deficient for Atm and overexpressing human Cu/Zn superoxide dismutase (SOD1). We report that elevated levels of SOD1 exacerbate specific features of the murine Atm- deficient phenotype, including abnormalities in hematopoiesis and radiosensitivity. The data are consistent with the possibility that oxidative stress contributes to some of the clinical features associated with the A-T phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.