ArticleThe Biochemical journal2001
Influence of metallothionein-1 localization on its function.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 68 citations in OpenAlex.
- Methamphetamine Induces Metallothionein 1 Expression and an Inflammatory Phenotype in Primary Human HIV-Infected Macrophages.International journal of molecular sciences · 2025Article
- Metallothionein 1: A New Spotlight on Inflammatory Diseases.Frontiers in immunology · 2021Review
- Transcriptome analysis of the liver ofPeerJ · 2021Article
- Microarray-based differential expression profiling of long noncoding RNAs and messenger RNAs in formalin-fixed paraffin-embedded human papillary thyroid carcinoma samples.Translational cancer research · 2019Article
- Increased Expression Levels of Metalloprotease, Tissue Inhibitor of Metalloprotease, Metallothionein, and p63 in Ectopic Endometrium: An Animal Experimental Study.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018Article
- The roles of metallothioneins in carcinogenesis.Journal of hematology & oncology · 2018Review
- Metallothionein induction in the coelomic fluid of the earthworm Lumbricus terrestris following heavy metal exposure: a short report.BioMed research international · 2014Article
- Role of metallothioneins in benign and malignant thyroid lesions.Thyroid research · 2012Article
- Molecular functions of metallothionein and its role in hematological malignancies.Journal of hematology & oncology · 2012Review
- Functional characterization of four metallothionein genes in Daphnia pulex exposed to environmental stressors.Aquatic toxicology (Amsterdam, Netherlands) · 2012Article
- Zinc transporters, mechanisms of action and therapeutic utility: implications for type 2 diabetes mellitus.Journal of nutrition and metabolism · 2012Article
- Hairpin DNA-functionalized gold colloids for the imaging of mRNA in live cells.Journal of the American Chemical Society · 2010Article
- Manipulations of metallothionein gene dose accelerate the response to Listeria monocytogenes.Chemico-biological interactions · 2009Article
- Fine mapping of interactions between eEF1alpha protein and 3'UTR of metallothionein-1 mRNA.Biochemical and biophysical research communications · 2009Article
- Expression of the PsMTA1 gene in white poplar engineered with the MAT system is associated with heavy metal tolerance and protection against 8-hydroxy-2'-deoxyguanosine mediated-DNA damage.Plant cell reports · 2009Article
- Evidence for a potential role of metallothioneins in inflammatory bowel diseases.Mediators of inflammation · 2009Review
- Comparison of RCAS1 and metallothionein expression and the presence and activity of immune cells in human ovarian and abdominal wall endometriomas.Reproductive biology and endocrinology : RB&E · 2006Article
- Elongation factor 1alpha binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization--importance of an internal stem-loop.RNA (New York, N.Y.) · 2006Article
- An eleven nucleotide section of the 3'-untranslated region is required for perinuclear localization of rat metallothionein-1 mRNA.The Biochemical journal · 2005Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metallothioneins (MTs) have a major role to play in metal metabolism, and may also protect DNA against oxidative damage. MT protein has been found localized in the nucleus during S-phase. The mRNA encoding the MT-1 isoform has a perinuclear localization, and is associated with the cytoskeleton; this targeting, due to signals within the 3'-untranslated region (3'-UTR), facilitates nuclear localization of MT-1 during S-phase [Levadoux, Mahon, Beattie, Wallace and Hesketh (1999) J. Biol. Chem. 274, 34961-34966]. Using cells transfected with MT gene constructs differing in their 3'-UTRs, the role of MT protein in the nucleus has been studied. Chinese hamster ovary cells were transfected with either the full MT gene (MTMT cells) or with the MT 5'-UTR and coding region linked to the 3'-UTR of glutathione peroxidase (MTGSH cells). Cell survival following exposure to oxidative stress and chemical agents was higher in cells expressing the native MT gene than in cells where MT localization was disrupted, or in untransfected cells. Also, MTMT cells showed less DNA damage than MTGSH cells in response to either hydrogen peroxide or mutagen. After exposure to UV light or mutagen, MTMT cells showed less apoptosis than MTGSH cells, as assessed by DNA fragmentation and flow cytometry. The data indicate that the perinuclear localization of MT mRNA is important for the function of MT in a protective role against DNA damage and apoptosis induced by external stress.
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