ArticleThe Biochemical journal2001
Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 65 citations in OpenAlex.
- Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway.Current medical science · 2023Article
- Upregulation of NUAK2: A novel prognostic marker in breast cancer.Histology and histopathology · 2023Article
- NUAK Kinases: Brain-Ovary Axis.Cells · 2021Review
- NUAK1 and NUAK2 Fine-Tune TGF-β Signaling.Cancers · 2021Review
- lncRNA FGD5‑AS1 promotes breast cancer progression by regulating the hsa‑miR‑195‑5p/NUAK2 axis.Molecular medicine reports · 2021Article
- A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling.The Journal of experimental medicine · 2020Article
- Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2019Article
- Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart.Journal of cellular biochemistry · 2019Article
- NUAK2 is a critical YAP target in liver cancer.Nature communications · 2018Article
- AMPK in skeletal muscle function and metabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Review
- The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.The Journal of clinical investigation · 2016Article
- Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes.PloS one · 2014Article
- The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling.Journal of hepatology · 2013Article
- NUAK2: an emerging acral melanoma oncogene.Oncotarget · 2011Review
- AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.Diabetologia · 2009Article
- The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci.Cancer science · 2008Article
- Potential Role of the AMP-activated Protein Kinase in Regulation of Insulin Action.Cellscience · 2006Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subtraction hybridization after the exposure of keratinocytes to ultraviolet radiation identified a differentially expressed cDNA that encodes a protein of 630 amino acid residues possessing significant similarity to the catalytic domain of the sucrose-non-fermenting protein kinase (SNF1)/AMP-activated protein kinase (AMPK) family of serine/threonine protein kinases. Northern blotting and reverse-transcriptase-mediated PCR demonstrated that mRNA transcripts for the SNF1/AMPK-related kinase (SNARK) were widely expressed in rodent tissues. The SNARK gene was localized to human chromosome 1q32 by fluorescent in situ hybridization. SNARK was translated in vitro to yield a single protein band of approx. 76 kDa; Western analysis of transfected baby hamster kidney (BHK) cells detected two SNARK-immunoreactive bands of approx. 76-80 kDa. SNARK was capable of autophosphorylation in vitro; immunoprecipitated SNARK exhibited phosphotransferase activity with the synthetic peptide substrate HMRSAMSGLHLVKRR (SAMS) as a kinase substrate. SNARK activity was significantly increased by AMP and 5-amino-4-imidazolecarboxamide riboside (AICAriboside) in rat keratinocyte cells, implying that SNARK might be activated by an AMPK kinase-dependent pathway. Furthermore, glucose deprivation increased SNARK activity 3-fold in BHK fibroblasts. These findings identify SNARK as a glucose- and AICAriboside-regulated member of the AMPK-related gene family that represents a new candidate mediator of the cellular response to metabolic stress.
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