ArticleMolecular and cellular biology2001
Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Phosphorylation of PA28γ by CK2 kinase facilitates HNSCC tumor formation and progression.Nature communications · 2025Article
- E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development.Nature communications · 2025Article
- Transcription factor E4F1 as a regulator of cell life and disease progression.Science advances · 2023Review
- The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.Nature communications · 2021Article
- Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice.Animals : an open access journal from MDPI · 2020Article
- Article
- EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation.PLoS pathogens · 2019Article
- E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Role of cyclins in controlling progression of mammalian spermatogenesis.The International journal of developmental biology · 2013Review
- E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.The Journal of experimental medicine · 2011Article
- Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish.The EMBO journal · 2011Article
- Cyclin A2 mutagenesis analysis: a new insight into CDK activation and cellular localization requirements.PloS one · 2011Article
- Article
- The CDK4-pRB-E2F1 pathway controls insulin secretion.Nature cell biology · 2009Article
- JunB breakdown in mid-/late G2 is required for down-regulation of cyclin A2 levels and proper mitosis.Molecular and cellular biology · 2008Article
- The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.EMBO reports · 2007Article
- The LIM-only protein FHL2 is a negative regulator of E4F1.Oncogene · 2006Article
- E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.Genes & development · 2006Article
- Cell type-dependent control of NF-Y activity by TGF-beta.Oncogene · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E4F is a ubiquitously expressed GLI-Krüppel-related transcription factor which has been identified for its capacity to regulate transcription of the adenovirus E4 gene in response to E1A. However, cellular genes regulated by E4F are still unknown. Some of these genes are likely to be involved in cell cycle progression since ectopic p120E4F expression induces cell cycle arrest in G1. Although p21WAF1 stabilization was proposed to mediate E4F-dependent cell cycle arrest, we found that p120E4F can induce a G1 block in p21(-/-) cells, suggesting that other proteins are essential for the p120E4F-dependent block in G1. We show here that cyclin A promoter activity can be repressed by p120E4F and that this repression correlates with p120E4F binding to the cyclic AMP-responsive element site of the cyclin A promoter. In addition, enforced expression of cyclin A releases p120E4F-arrested cells from the G1 block. These data identify the cyclin A gene as a cellular target for p120E4F and suggest a mechanism for p120E4F-dependent cell cycle regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.