ArticleThe Journal of physiology2001
Sustained sensitization and recruitment of rat cutaneous nociceptors by bradykinin and a novel theory of its excitatory action.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 127 citations in OpenAlex.
- Nobel somatosensations and pain.Pflugers Archiv : European journal of physiology · 2022Review
- The ultraviolet B inflammation model: Postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects.European journal of pain (London, England) · 2019Article
- Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception.Biomolecules & therapeutics · 2018Review
- Mechanically sensitive Aδ nociceptors that innervate bone marrow respond to changes in intra-osseous pressure.The Journal of physiology · 2017Article
- The role of corneal afferent neurons in regulating tears under normal and dry eye conditions.Experimental eye research · 2013Review
- Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells.Journal of neurophysiology · 2013Article
- Article
- Evidence for shared pain mechanisms in osteoarthritis, low back pain, and fibromyalgia.Current rheumatology reports · 2011Review
- Pathophysiology of postoperative pain.Pain · 2011Review
- Article
- Bradykinin and thromboxane A2 reciprocally interact to synergistically stimulate cardiac spinal afferents during myocardial ischemia.American journal of physiology. Heart and circulatory physiology · 2010Article
- Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro.Experimental brain research · 2009Review
- Excitation and sensitization of nociceptors by bradykinin: what do we know?Experimental brain research · 2009Review
- Phenotyping sensory nerve endings in vitro in the mouse.Nature protocols · 2009Article
- Sensory transduction in peripheral nerve axons elicits ectopic action potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture study.Arthritis research & therapy · 2007Article
- Arthritis and pain. Future targets to control osteoarthritis pain.Arthritis research & therapy · 2007Review
- Interactions between histamine and bradykinin in stimulation of ischaemically sensitive cardiac afferents in felines.The Journal of physiology · 2005Article
- Article
- Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excitation and sensitization to heat of nociceptors by bradykinin (BK) were examined using an isolated rat skin-saphenous nerve preparation. A total of 52 C-fibres was tested: 42 were mechano-heat sensitive (CMH) and 40% of them were excited and sensitized to heat by BK superfusion (10-5 M, 5 min) of their receptive fields; heat responses were augmented by more than five times and heat thresholds dropped to 36.4 degrees C, on average. Sixty per cent of the CMH did not respond to BK itself, but 3/4 of these units showed an increase in their heat responses by more than 100% following BK exposure. Ten high-threshold mechanosensitive C-fibres did not discharge upon BK application but following this five of them responded to heat in a well-graded manner. In all fibres, the sensitizing effect of BK was abolished within 9 min or less of wash-out, and it could be reproduced several times at equal magnitude, whereas the excitatory effect of BK regularly showed profound tachyphylaxis. Sustained superfusion (20 min) of BK induced a desensitizing excitatory response while superimposed heat responses showed constant degrees of sensitization. The large extent and high prevalence of BK-induced sensitization (almost 80% of all fibres tested) and de novo recruitment of heat sensitivity suggest a prominent role of BK not only in hyperalgesia but also in sustained inflammatory pain which may be driven by body or even lower local temperatures acting on sensitized nociceptors. Based on the latter assumption, a hypothesis is put forward that excludes a direct excitatory effect of BK on nociceptors, but assumes a temperature-controlled activation as a result of rapid and profound sensitization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.