ArticleJournal of clinical microbiology2001
B-Cell epitope mapping of the VapA protein of Rhodococcus equi: implications for early detection of R. equi disease in foals.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Role of Peptides in Diagnostics.International journal of molecular sciences · 2021Review
- Humoral and cellular immune responses to Yersinia pestis Pla antigen in humans immunized with live plague vaccine.PLoS neglected tropical diseases · 2018Article
- Identification of a novel infection-enhancing epitope on dengue prM using a dengue cross-reacting monoclonal antibody.BMC microbiology · 2013Article
- Diagnostic peptide discovery: prioritization of pathogen diagnostic markers using multiple features.PloS one · 2012Article
- Transcytosis-blocking abs elicited by an oligomeric immunogen based on the membrane proximal region of HIV-1 gp41 target non-neutralizing epitopes.Current HIV research · 2008Article
- Article
- Mapping of B-cell epitopes on a novel 11.5-kilodalton Fasciola hepatica-Schistosoma mansoni cross-reactive antigen belonging to a member of the F. hepatica saposin-like protein family.Infection and immunity · 2006Article
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Authors and funding
3 authors.
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Abstract
Linear B-cell epitopes of the Rhodococcus equi virulence-associated protein (VapA) were mapped using a synthetic peptide bank in this study. The peptides were screened in an enzyme-linked immunosorbent assay (ELISA) with a total of 70 sera from foals with current R. equi disease (51 sera), as well as from foals that had either recovered from R. equi infection 10 months previously (3 sera) or that had no known history of R. equi disease (16 sera). An epitope with the sequence NLQKDEPNGRA was identified and was universally recognized by all 51 sera from foals with R. equi disease and was not recognized by any of the other sera. There was poor reactivity between all sera and peptides relating to other areas of the VapA protein. It is proposed that an ELISA based upon a defined peptide epitope may be used in an improved serological diagnostic test for R. equi infection in foals.
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