ArticleJournal of clinical microbiology2001
Molecular characterization of invasive and noninvasive Campylobacter jejuni and Campylobacter coli isolates.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 122 citations in OpenAlex.
- Pigeons as overlooked vectors: investigating Campylobacter carriage across different management systems.BMC veterinary research · 2026Article
- Antibiotic resistance profile of Campylobacter species recovered from some freshwater milieu in the Eastern Cape Province, South Africa.BMC microbiology · 2025Article
- Prevalence, antibiotic resistance, resistance and virulence determinants ofOne health (Amsterdam, Netherlands) · 2025Review
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- Genotyping and antibiotic susceptibility of Campylobacter species isolated from raw milk samples in Qazvin, Iran.BMC research notes · 2023Article
- Genotypic characterization, antimicrobial susceptibility and virulence determinants ofFrontiers in microbiology · 2023Article
- Wildlife Waterfowl as a Source of PathogenicPathogens (Basel, Switzerland) · 2022Article
- Genetic relatedness, virulence, and drug susceptibility ofFrontiers in cellular and infection microbiology · 2022Article
- Genomic and Phenotypic Characteristics in Geographically Separated ClinicalMicroorganisms · 2021Article
- Identification of pathogenic genes in Campylobacter jejuni isolated from broiler carcasses and broiler slaughterhouses.Scientific reports · 2021Article
- Occurrence, Virulence and Antimicrobial Resistance-Associated Markers inAntibiotics (Basel, Switzerland) · 2020Article
- Antimicrobial Resistance and Virulence Properties ofAnimals : an open access journal from MDPI · 2020Article
- Virulence Traits of InpatientMicroorganisms · 2020Article
- Campylobacteriosis Agents in Meat Carcasses Collected from Two District Municipalities in the Eastern Cape Province, South Africa.Foods (Basel, Switzerland) · 2020Article
- Genomic and Phenotypic Characterisation ofFrontiers in cellular and infection microbiology · 2020Article
- In vitro assessment of immunomodulatory and anti-Campylobacter activities of probiotic lactobacilli.Scientific reports · 2019Article
- Pathogenomics of EmergingClinical microbiology reviews · 2019Review
- Prevalence, Virulence, and Antimicrobial Resistance ofFoods (Basel, Switzerland) · 2019Article
- Campylobacter at the Human-Food Interface: The African Perspective.Pathogens (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Campylobacter jejuni is one of the most common causes of bacterial diarrhea worldwide and is the primary bacterial cause of food-borne illness. Adherence to and invasion of epithelial cells are the most important pathogenic mechanisms of Campylobacter diarrhea. Molecular characterization of invasive and noninvasive Campylobacter isolates from children with diarrhea and symptom-free children was performed by random amplified polymorphic DNA techniques (RAPD). A distinct RAPD profile with a DNA band of 1.6 kb was observed significantly more frequently among invasive (63%) than among noninvasive (16%) Campylobacter isolates (P = 0.000005). The 1.6-kb band was named the invasion-associated marker (IAM). Using specifically designed primers, a fragment of 518 bp of the iam locus was amplified in 85% of invasive and 20% of noninvasive strains (P = 0.0000000). Molecular typing with a PCR-restriction fragment length polymorphism assay which amplified the entire iam locus showed a HindIII restriction fragment polymorphism pattern associated mainly with invasive strains. Although cluster analysis of the RAPD fingerprinting showed genetic diversity among strains, two main clusters were identified. Cluster I comprised significantly more pathogenic and invasive isolates, while cluster II grouped the majority of nonpathogenic, noninvasive isolates. These data indicate that most of the invasive Campylobacter strains could be differentiated from noninvasive isolates by RAPD analysis and PCR using specific primers that amplify a fragment of the iam locus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.