ArticleJournal of clinical microbiology2001
Helicobacter pylori infection in an urban African population.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence and patterns of peptic ulcer disease in Africa: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Indications and endoscopic findings of upper gastrointestinal diseases in Africa: A systematic review & meta-analysis.PloS one · 2025Pooled it
- Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana.World journal of gastroenterology · 2019Pooled it
- Short term micronutrient-antioxidant supplementation has no impact on a serological marker of gastric atrophy in Zambian adults: retrospective analysis of a randomised controlled trial.BMC gastroenterology · 2014Trial
- Gastric and intestinal barrier impairment in tropical enteropathy and HIV: limited impact of micronutrient supplementation during a randomised controlled trial.BMC gastroenterology · 2010Trial
- A Scoping Review of the Associations Between Ascariasis, Helicobacter pylori Infection and Gastric Pathologies.Parasite immunology · 2026Article
- Prevalence of Clarithromycin-Resistant Helicobacter pylori Strains in Zambia: A Sub-Saharan African Country.Digestive diseases (Basel, Switzerland) · 2024Article
- Serum antibodies to selectedMalawi medical journal : the journal of Medical Association of Malawi · 2022Article
- Biomass Smoke Exposure Is Associated With Gastric Cancer and Probably Mediated Via Oxidative Stress and DNA Damage: A Case-Control Study.JCO global oncology · 2020Article
- The ProbioticFrontiers in microbiology · 2018Review
- Diagnostic yield of gastrointestinal endoscopy in North West Region Cameroon and trends in diagnosis over time.The Pan African medical journal · 2018Article
- High prevalence of gastric intestinal metaplasia detected by confocal laser endomicroscopy in Zambian adults.PloS one · 2017Article
- Association between Helicobacter pylori and intestinal parasites in an Añu indigenous community of Venezuela.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Article
- Production of IFN-γ and IL-4 Against Intact Catalase and Constructed Catalase Epitopes of Helicobacter pylori From T-Cells.Jundishapur journal of microbiology · 2015Article
- Trends in upper gastrointestinal diagnosis over four decades in Lusaka, Zambia: a retrospective analysis of endoscopic findings.BMC gastroenterology · 2015Article
- Helicobacter pylori infection in pregnant women in four districts of Uganda: role of geographic location, education and water sources.BMC public health · 2014Article
- Noncommunicable diseases in HIV infection in low- and middle-income countries: gastrointestinal, hepatic, and nutritional aspects.Journal of acquired immune deficiency syndromes (1999) · 2014Review
- Seroepidemiology of hepatitis E virus infection in an urban population in Zambia: strong association with HIV and environmental enteropathy.The Journal of infectious diseases · 2014Article
- Population genetic structure and isolation by distance of Helicobacter pylori in Senegal and Madagascar.PloS one · 2014Article
- Gastric cancer in Zambian adults: a prospective case-control study that assessed dietary intake and antioxidant status by using urinary isoprostane excretion.The American journal of clinical nutrition · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied 221 adults drawn from an impoverished urban population with high human immunodeficiency virus (HIV) seroprevalence (35%) to determine the prevalence of gastroduodenal pathology and its relationship to serological markers of Helicobacter pylori virulence proteins and other potential environmental and immunological determinants of disease including HIV infection. Eighty-one percent were H. pylori seropositive, and 35% were HIV seropositive. Urban upbringing and low CD4 count were associated with a reduced likelihood of H. pylori seropositivity, as was current Ascaris infection, in keeping with recent evidence from an animal model. One hundred ninety-one adults underwent gastroduodenoscopy, and 14 had gastroduodenal pathology. Mucosal lesions were a major cause of abdominal pain in this population. While the majority of patients with gastroduodenal pathology (12 of 14) were seropositive for H. pylori, none were seropositive for HIV. Smoking was associated with increased risk of macroscopic pathology, and a history of Mycobacterium bovis BCG immunization was associated with reduced risk. Antibodies to H. pylori lipopolysaccharide were associated with pathology. HIV infection was associated with protection against mucosal lesions, suggesting that fully functional CD4 lymphocytes may be required for the genesis of gastroduodenal pathology.
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