ArticleGenome research2001
Characterization of clustered MHC-linked olfactory receptor genes in human and mouse.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator.BMC medicine · 2024Trial
- Motor Cortex Disinhibition Correlates with Olfactory Dysfunction in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Influence of MHC on genetic diversity and testicular expression of linked olfactory receptor genes.BMC genomics · 2025Article
- Prediction of Tumor Microenvironment Characteristics and Treatment Response in Lung Squamous Cell Carcinoma by Pseudogene OR7E47P-related Immune Genes.Current medical science · 2023Article
- Genome-wide association analysis of heifer livability and early first calving in Holstein cattle.BMC genomics · 2023Article
- Functional studies of HLA and its role in SARS-CoV-2: Stimulating T cell response and vaccine development.Life sciences · 2023Review
- The immune mechanism of the nasal epithelium in COVID-19-related olfactory dysfunction.Frontiers in immunology · 2023Review
- Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?Nature reviews. Neuroscience · 2022Review
- Genomic Copy Number Variation Study of Nine Macaca Species Provides New Insights into Their Genetic Divergence, Adaptation, and Biomedical Application.Genome biology and evolution · 2020Article
- Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Review
- Individual olfactory perception reveals meaningful nonolfactory genetic information.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species.Immunogenetics · 2010Review
- Self/nonself perception, reproduction and the extended MHC.Self/nonself · 2010Article
- Characterising functionally important and ecologically meaningful genetic diversity using a candidate gene approach.Genetica · 2010Review
- Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors.Human immunology · 2010Article
- Risk for intentional violent death associated with HLA genotypes: a preliminary survey of deceased American organ donors.Genetica · 2009Article
- Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex.Genetic testing · 2008Article
- Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat.PloS one · 2008Article
- Sympatric speciation as intrinsic property of the expanding population.Theory in biosciences = Theorie in den Biowissenschaften · 2007Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Olfactory receptor (OR) loci frequently cluster and are present on most human chromosomes. They are members of the seven transmembrane receptor (7-TM) superfamily and, as such, are part of one of the largest mammalian multigene families, with an estimated copy number of up to 1000 ORs per haploid genome. As their name implies, ORs are known to be involved in the perception of odors and possibly also in other, nonolfaction-related, functions. Here, we report the characterization of ORs that are part of the MHC-linked OR clusters in human and mouse (partial sequence only). These clusters are of particular interest because of their possible involvement in olfaction-driven mate selection. In total, we describe 50 novel OR loci (36 human, 14 murine), making the human MHC-linked cluster the largest sequenced OR cluster in any organism so far. Comparative and phylogenetic analyses confirm the cluster to be MHC-linked but divergent in both species and allow the identification of at least one ortholog that will be useful for future regulatory and functional studies. Quantitative feature analysis shows clear evidence of duplications of blocks of OR genes and reveals the entire cluster to have a genomic environment that is very different from its neighboring regions. Based on in silico transcript analysis, we also present evidence of extensive long-distance splicing in the 5'-untranslated regions and, for the first time, of alternative splicing within the single coding exon of ORs. Taken together with our previous finding that ORs are also polymorphic, the presented data indicate that the expression, function, and evolution of these interesting genes might be more complex than previously thought.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.