SynthesisBMJ (Clinical research ed.)2001
Dietary fat intake and prevention of cardiovascular disease: systematic review.
Synthesis in BMJ (Clinical research ed.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 22 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 22 syntheses or guidelines pooled it.
- Interventions for primary prevention of cardiovascular disease: umbrella review of systematic reviews.Health technology assessment (Winchester, England) · 2025Pooled it
- Primary and secondary cardiovascular disease prevention interventions targeting lifestyle risk factors in women: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of total fat intake on body fatness in adults.The Cochrane database of systematic reviews · 2020Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- A systematic review of neighbourhood economic context on child obesity and obesity-related behaviours.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Pooled it
- Effects of total fat intake on bodyweight in children.The Cochrane database of systematic reviews · 2018Pooled it
- Effects of total fat intake on bodyweight in children.The Cochrane database of systematic reviews · 2018Pooled it
- Niacin for primary and secondary prevention of cardiovascular events.The Cochrane database of systematic reviews · 2017 · on this mapPooled it
- Fibrates for primary prevention of cardiovascular disease events.The Cochrane database of systematic reviews · 2016 · on this mapPooled it
- Effects of total fat intake on body weight.The Cochrane database of systematic reviews · 2015Pooled it
- Dietary fatty acids in the secondary prevention of coronary heart disease: a systematic review, meta-analysis and meta-regression.BMJ open · 2014Pooled it
- Effectiveness of interventions to promote healthy diet in primary care: systematic review and meta-analysis of randomised controlled trials.BMC public health · 2013Pooled it
- Fish oil administration in older adults: is there potential for adverse events? A systematic review of the literature.BMC geriatrics · 2013Pooled it
- A systematic review of randomized controlled trials on the effectiveness of computer-tailored physical activity and dietary behavior promotion programs: an update.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2012Pooled it
- Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2012Pooled it
- Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2011Pooled it
- Primary prevention of CVD: treating dyslipidaemia.BMJ clinical evidence · 2010Pooled it
- Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials.PLoS medicine · 2010Pooled it
- Application of systematic review methodology to the field of nutrition.The Journal of nutrition · 2008Pooled it
36 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effect of reduction or modification of dietary fat intake on total and cardiovascular mortality and cardiovascular morbidity.
designSystematic review. DATA SOURCES: Cochrane Library, Medline, Embase, CAB abstracts, SIGLE, CVRCT registry, and biographies were searched; trials known to experts were included. INCLUDED STUDIES: Randomised controlled trials stating intention to reduce or modify fat or cholesterol intake in healthy adult participants over at least six months. Inclusion decisions, validity, and data extraction were duplicated. Meta-analysis (random effects methodology), meta-regression, and funnel plots were performed.
results27 studies (30 902 person years of observation) were included. Alteration of dietary fat intake had small effects on total mortality (rate ratio 0.98; 95% confidence interval 0.86 to 1.12). Cardiovascular mortality was reduced by 9% (0.91; 0.77 to 1.07) and cardiovascular events by 16% (0.84; 0.72 to 0.99), which was attenuated (0.86; 0.72 to 1.03) in a sensitivity analysis that excluded a trial using oily fish. Trials with at least two years' follow up provided stronger evidence of protection from cardiovascular events (0.76; 0.65 to 0.90).
conclusionsThere is a small but potentially important reduction in cardiovascular risk with reduction or modification of dietary fat intake, seen particularly in trials of longer duration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.