ArticleDigestive diseases and sciences2001
Intestinal growth adaptation and glucagon-like peptide 2 in rats with ileal--jejunal transposition or small bowel resection.
Article in Digestive diseases and sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Actions of glucagon-like peptide-1 receptor ligands in the gut.British journal of pharmacology · 2022Review
- Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors.Frontiers in endocrinology · 2021Article
- Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2018Article
- Maternal ileal interposition surgery confers metabolic improvements to offspring independent of effects on maternal body weight in UCD-T2DM rats.Obesity surgery · 2013Article
- Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats.Endocrinology · 2012Article
- Surgical treatment of type 2 diabetes in patients with BMI below 35: mid-term outcomes of the laparoscopic ileal interposition associated with a sleeve gastrectomy in 202 consecutive cases.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
- Surgical treatment of morbid obesity: mid-term outcomes of the laparoscopic ileal interposition associated to a sleeve gastrectomy in 120 patients.Obesity surgery · 2011Article
- Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Growth factors: possible roles for clinical management of the short bowel syndrome.Seminars in pediatric surgery · 2010Review
- Article
- Morphological, kinetic, membrane biochemical and genetic aspects of intestinal enteroplasticity.World journal of gastroenterology · 2009Review
- Intestinal hormones and growth factors: effects on the small intestine.World journal of gastroenterology · 2009Review
- Enterohormonal changes after digestive adaptation: five-year results of a surgical proposal to treat obesity and associated diseases.Obesity surgery · 2008Article
- Intestinal epithelial cell proliferation is dependent on the site of massive small bowel resection.Pediatric surgery international · 2007Article
- Intestinal mucosal adaptation.World journal of gastroenterology · 2006Review
- Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens.Digestive diseases and sciences · 2004Article
- Article
- Enhancing bowel adaptation in short bowel syndrome.Current gastroenterology reports · 2002Review
- Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats.JPEN. Journal of parenteral and enteral nutritionArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucagon-like peptide 2 (GLP-2), produced by enteroendocrine L-cells, regulates intestinal growth. This study investigates circulating and intestinal GLP-2 levels in conditions with altered L-cell exposure to nutrients. Rats were allocated to the following experimental groups: ileal-jejunal transposition, resection of the proximal or distal half of the small intestine, and appropriate sham-operated controls. After two weeks, ileal-jejunal transposition led to pronounced growth of the transposed segment and also of the remaining intestinal segments. Plasma GLP-2 levels increased twofold, whereas GLP-2 levels in the intestinal segments were unchanged. In resected rats with reduced intestinal capacity, adaptive small bowel growth was more pronounced following proximal resection than distal small bowel resection. Circulating GLP-2 levels increased threefold in proximally resected animals, and twofold in the distally resected group. Tissue GLP-2 levels were unchanged in resected rats. The data indicate that transposition of a distal part of the small intestine, and thereby exposure of L cells to a more nutrient-rich chyme, leads to intestinal growth. The adaptive intestinal growth is associated with increased plasma levels of GLP-2, and GLP-2 seems to act in an endocrine as well as a paracrine manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.