SynthesisThe Cochrane database of systematic reviews2001
Magnesium sulphate versus lytic cocktail for eclampsia.
Synthesis in The Cochrane database of systematic reviews, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy.BMC public health · 2011Pooled it
- Magnesium sulphate versus diazepam for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate versus phenytoin for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate versus lytic cocktail for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Alternative magnesium sulphate regimens for women with pre-eclampsia and eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Reducing stillbirths: interventions during labour.BMC pregnancy and childbirth · 2009Pooled it
- The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months.BJOG : an international journal of obstetrics and gynaecology · 2007Trial
- Article
- Atypical Presentation of Antenatal Eclampsia.Cureus · 2022Article
- Use of Antihypertensive Drugs During Preeclampsia.Frontiers in cardiovascular medicine · 2018Article
- The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial.Iranian journal of neurology · 2017Article
- Maternal outcomes of magnesium sulphate and diazepam use in women with severe pre-eclampsia and eclampsia in Ethiopia.Pharmacy practice · 2014Article
- The Impact of Magnesium Sulfate Therapy on Angiogenic Factors in Preeclampsia.Pregnancy hypertension · 2012Article
- Public health perspectives of preeclampsia in developing countries: implication for health system strengthening.Journal of pregnancy · 2011Review
- Identifying barriers to the availability and use of Magnesium Sulphate Injection in resource poor countries: a case study in Zambia.BMC health services research · 2010Article
- Evidence for perinatal and child health care guidelines in crisis settings: can Cochrane help?BMC public health · 2010Article
- Epidemiology of Maternal Mortality in Malawi.Malawi medical journal : the journal of Medical Association of Malawi · 2006Article
- Continuing medical education in Brazil: what about obstetricians and gynecologists?Sao Paulo medical journal = Revista paulista de medicina · 2005Article
- The Magpie Trial follow up study: outcome after discharge from hospital for women and children recruited to a trial comparing magnesium sulphate with placebo for pre-eclampsia [ISRCTN86938761].BMC pregnancy and childbirth · 2004Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEclampsia, the occurrence of a seizure in association with pre-eclampsia, is a rare but serious complication of pregnancy. A number of different anticonvulsants are used to control eclamptic fits and to prevent further seizures.
objectivesThe aim of this review was to compare the effects of magnesium sulphate with those of lytic cocktail when used for the care of women with eclampsia. SEARCH STRATEGY: The register of trials held by the Cochrane Pregnancy and Childbirth Group was searched for relevant trials. The Cochrane Controlled Trials Register in The Cochrane Library Issue 2, 2000 was also searched. SELECTION CRITERIA: Randomised trials recruiting women with eclampsia, and comparing any use of magnesium sulphate with any use of lytic cocktail. DATA COLLECTION AND ANALYSIS: Data were extracted from each report without any blinding of the results or of the treatments which women received. MAIN
resultsTwo trials with 199 women were included in the review. These were both small and of average quality. Magnesium sulphate was better than lytic cocktail at preventing further fits (relative risk (RR) 0.09, 95% confidence interval (CI) 0.03-0.24; risk difference (RD) 0.43, 95% CI -0.53, -0.34; number needed to treat (NNT) 3, 95% CI 2-3) and was associated with less respiratory depression (RR 0.12, 95% CI 0.02-0.91). Magnesium sulphate was also associated with fewer maternal deaths than lytic cocktail, but the difference was not statistically significant (RR 0.25, 95% CI 0.04-1.43). REVIEWER'S
conclusionsMagnesium sulphate is the anticonvulsant of choice for women with eclampsia. Lytic cocktail should be abandoned.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.