ArticleProceedings of the National Academy of Sciences of the United States of America2001
Differences in quantal amplitude reflect GluR4- subunit number at corticothalamic synapses on two populations of thalamic neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 265 citations in OpenAlex.
- Value and mechanisms of EEG reactivity in the prognosis of patients with impaired consciousness: a systematic review.Critical care (London, England) · 2018Pooled it
- FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems.iScience · 2025Article
- Molecular Mechanisms Underlying the Generation of Absence Seizures: Identification of Potential Targets for Therapeutic Intervention.International journal of molecular sciences · 2024Review
- Article
- Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.bioRxiv : the preprint server for biology · 2024Article
- Parvalbumin Interneuron Dysfunction in Neurological Disorders: Focus on Epilepsy and Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness.Nature communications · 2024Article
- Sleep and wake in a model of the thalamocortical system with Martinotti cells.The European journal of neuroscience · 2024Article
- Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits.Network neuroscience (Cambridge, Mass.) · 2023Article
- Layer 5 of cortex innervates the thalamic reticular nucleus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Impact of Glutamatergic Synapse Dysfunction in the Corticothalamocortical Network on Absence Seizure Generation.Frontiers in molecular neuroscience · 2022Review
- Corticothalamic feedback sculpts visual spatial integration in mouse thalamus.Nature neuroscience · 2021Article
- Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury.Science (New York, N.Y.) · 2021Article
- Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle.Nature reviews. Neuroscience · 2021Review
- Article
- Corticothalamic Pathways in Auditory Processing: Recent Advances and Insights From Other Sensory Systems.Frontiers in neural circuits · 2021Review
- Synaptic Adaptation Contributes to Stimulus-Specific Adaptation in the Thalamic Reticular Nucleus.Neuroscience bulletin · 2020Article
- Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures.Brain : a journal of neurology · 2020Review
- How Sleep Shapes Thalamocortical Circuit Function in the Visual System.Annual review of vision science · 2019Review
- The Brain Network in a Model of Thalamocortical Dysrhythmia.Brain connectivity · 2019Article
39 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
Funding
Abstract
Low-frequency thalamocortical oscillations that underlie drowsiness and slow-wave sleep depend on rhythmic inhibition of relay cells by neurons in the reticular nucleus (RTN) under the influence of corticothalamic fibers that branch to innervate RTN neurons and relay neurons. To generate oscillations, input to RTN predictably should be stronger so disynaptic inhibition of relay cells overcomes direct corticothalamic excitation. Amplitudes of excitatory postsynaptic conductances (EPSCs) evoked in RTN neurons by minimal stimulation of corticothalamic fibers were 2.4 times larger than in relay neurons, and quantal size of RTN EPSCs was 2.6 times greater. GluR4-receptor subunits labeled at corticothalamic synapses on RTN neurons outnumbered those on relay cells by 3.7 times, providing a basis for differences in synaptic strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.