ArticleProceedings of the National Academy of Sciences of the United States of America2001
Mutations in Drosophila heat shock cognate 4 are enhancers of Polycomb.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Polycomb RequiresFrontiers in cell and developmental biology · 2021Article
- Polycomb group proteins are required to couple seed coat initiation to fertilization.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Nuclear matrix proteome analysis of Drosophila melanogaster.Molecular & cellular proteomics : MCP · 2010Article
- Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes.The EMBO journal · 2007Article
- Phenotypic plasticity in Drosophila pigmentation caused by temperature sensitivity of a chromatin regulator network.PLoS genetics · 2007Article
- The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.Molecular and cellular biology · 2005Article
- Cross-regulation among the polycomb group genes in Drosophila melanogaster.Molecular and cellular biology · 2004Article
- The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.Molecular and cellular biology · 2002Article
- Drosophila cyclin E interacts with components of the Brahma complex.The EMBO journal · 2002Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homeotic genes controlling segment identity in Drosophila are repressed by the Polycomb group of genes (PcG) and are activated by genes of the trithorax group (trxG). An F(1) screen for dominant enhancers of Polycomb yielded a point mutation in the heat shock cognate gene, hsc4, along with mutations corresponding to several known PcG loci. The new mutation is a more potent enhancer of Polycomb phenotypes than an apparent null allele of hsc4 is, although even the null allele occasionally displays homeotic phenotypes associated with the PcG. Previous biochemical results had suggested that HSC4 might interact with BRAHMA, a trxG member. Further analyses now show that there is no physical or genetic interaction between HSC4 and the Brahma complex. HSC4 might be needed for the proper folding of a component of the Polycomb repression complex, or it may be a functional member of that complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.