ArticleJournal of bacteriology2001
An alpha/beta-type, small, acid-soluble spore protein which has very high affinity for DNA prevents outgrowth of Bacillus subtilis spores.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Dry versus wet dormancy: suspended lives ofmSystems · 2026Review
- The small acid-soluble proteins of spore-forming organisms: similarities and differences in function.Anaerobe · 2024Review
- Novel antimicrobial strategies to treat multi-drug resistant Staphylococcus aureus infections.Microbial biotechnology · 2023Review
- Effect of oxygen on the germination and culturability of Bacillus atrophaeus spores.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Engineered Bacteriophage as a Delivery Vehicle for Antibacterial Protein, SASP.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Levels and Characteristics of mRNAs in Spores of Firmicute Species.Journal of bacteriology · 2021Article
- Bacterial Spore mRNA - What's Up With That?Frontiers in microbiology · 2020Review
- Properties of Aged Spores of Bacillus subtilis.Journal of bacteriology · 2019Article
- Analysis of the mRNAs in Spores of Bacillus subtilis.Journal of bacteriology · 2019Article
- Photochemistry and Photobiology of the Spore Photoproduct: A 50-Year Journey.Photochemistry and photobiology · 2015Review
- Phosphoproteome dynamics mediate revival of bacterial spores.BMC biology · 2015Article
- Fighting Ebola with novel spore decontamination technologies for the military.Frontiers in microbiology · 2015Article
- Crystallization and preliminary X-ray analysis of the complex between a Bacillus subtilis alpha/beta-type small acid-soluble spore protein and DNA.Acta crystallographica. Section F, Structural biology and crystallization communications · 2007Article
- A method for extracting RNA from dormant and germinating Bacillus subtilis strain 168 endospores.Current microbiology · 2006Article
- Effects of carboxy-terminal modifications and pH on binding of a Bacillus subtilis small, acid-soluble spore protein to DNA.Journal of bacteriology · 2003Article
- Small, acid-soluble proteins as biomarkers in mass spectrometry analysis of Bacillus spores.Applied and environmental microbiology · 2003Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A derivative of SspC, a minor alpha/beta-type, small, acid-soluble spore protein (SASP) from Bacillus subtilis, was generated that has a very high affinity for DNA. This protein (SspC(Delta11-D13K)) was able to confer UV resistance on spores lacking alpha/beta-type SASP, and spores with SspC(Delta11-D13K) triggered germination normally. However, SspC(Delta11-D13K) blocked outgrowth of > or = 90% of germinated spores, and SspC(Delta11-D13K) persisted in these germinated spores, whereas wild-type SspC was almost completely degraded. The outgrowth phenotype of spores with SspC(Delta11-D13K) is proposed to be due to the high stability of the SspC(Delta11-D13K)-DNA complex, which prevents rapid degradation of this alpha/beta-type SASP early in germination. The persistence of this protein on spore DNA then interferes with transcription during spore outgrowth.
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Registered trials
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