ArticleJournal of clinical pathology2001
Nuclear beta catenin expression is related to unfavourable outcome in oropharyngeal and hypopharyngeal squamous cell carcinoma.
Article in Journal of clinical pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Prognostic Significance of β-Catenin in Relation to the Tumor Immune Microenvironment in Oral Cancer.Biomedicines · 2023Article
- Prognostic significance of E-Cadherin, β-Catenin and cyclin D1 in oral squamous cell carcinoma: a tissue microarray study.Histology and histopathology · 2021Article
- Forkhead box protein O3a promotes glioma cell resistance to temozolomide by regulating matrix metallopeptidase and β-catenin.Oncology letters · 2021Article
- The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas.Cells · 2020Review
- Interactions of human MSC with head and neck squamous cell carcinoma cell line PCI-13 reduce markers of epithelia-mesenchymal transition.Clinical oral investigations · 2015Article
- Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer.Cancer research · 2014Article
- Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression.BMC cancer · 2011Article
- Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer.Molecular cancer · 2010Article
- Versican expression in pharyngeal squamous cell carcinoma: an immunohistochemical study.Journal of clinical pathology · 2004Article
- The role of E-cadherin/beta-catenin complex and cyclin D1 in head and neck squamous cell carcinoma.Cancer research and treatment · 2004Article
- Motility-related protein-1 (MRP-1/CD9) expression can predict disease-free survival in patients with squamous cell carcinoma of the head and neck.British journal of cancer · 2004Article
- acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx.Journal of clinical pathology · 2003Review
- Article
- Reduced expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer.Journal of clinical pathology · 2001Article
- Immunohistochemical Expression of E-Cadherin and β-Catenin in Oral Squamous Cell Carcinoma.Journal of the West African College of SurgeonsArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the expression of alpha, beta, and gamma catenins in oropharyngeal and hypopharyngeal squamous cell carcinoma and their relations to each other, as well as to clinical data, tumour differentiation, and prognosis.
methodsPrimary tumours for analysis were obtained from 138 patients diagnosed with squamous cell carcinoma of the oropharynx or hypopharynx between 1975 and 1998 in eastern Finland. Immunohistochemistry was used to evaluate the expression of alpha, beta, and gamma catenins. The expression patterns of all catenins were related to clinical data and survival.
resultsThe expression patterns of all three catenins were significantly interrelated. Reduced gamma catenin expression was significantly associated with poor histological differentiation. No association was found between alpha or beta catenin expression and clinicopathological characteristics. In univariate analysis, patients whose tumours had nuclear beta catenin expression had shorter overall survival than patients with no nuclear expression. In Cox multivariate analysis, nuclear beta catenin expression, tumour status (T class), and Karnofsky performance index were independent prognostic factors of overall survival.
conclusionsReduced expression of gamma catenin is associated with dedifferentiation in primary squamous cell carcinoma of the oropharynx and hypopharynx. The fact that nuclear beta catenin expression independently predicts short overall survival suggests that it might be a valuable prognostic marker in pharyngeal squamous cell carcinoma.
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