ArticleEMBO reports2000
Uncoupling yeast intron recognition from transcription with recursive splicing.
Article in EMBO reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Emerging and re-emerging themes in co-transcriptional pre-mRNA splicing.Molecular cell · 2024Review
- The determinants of alternative RNA splicing in human cells.Molecular genetics and genomics : MGG · 2017Review
- Sequencing of lariat termini in S. cerevisiae reveals 5' splice sites, branch points, and novel splicing events.RNA (New York, N.Y.) · 2016Article
- Cutting a Long Intron Short: Recursive Splicing and Its Implications.Frontiers in physiology · 2016Article
- Quantification of pre-mRNA escape rate and synergy in splicing.Nucleic acids research · 2014Article
- A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional.Molecular cell · 2006Article
- Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA.RNA (New York, N.Y.) · 2006Article
- ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs.The Journal of cell biology · 2005Article
- Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae.RNA (New York, N.Y.) · 2003Article
- Cotranscriptional recruitment of the U1 snRNP to intron-containing genes in yeast.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pre-mRNA splicing has to be coordinated with other processes occurring in the nucleus including transcription, mRNA 3' end formation and mRNA export. To analyze the relationship between transcription and splicing, we constructed a network of nested introns. Introns were inserted in the 5' splice site and/or branchpoint of a synthetic yeast intron interrupting a reporter gene. The inserted introns mask the recipient intron from the cellular machinery until they are removed by splicing. Production of functional mRNA from these constructs therefore requires recognition of a spliced RNA as a splicing substrate. We show that recurrent splicing occurs in a sequential and ordered fashion in vivo. Thus, in Saccharomyces cerevisiae, intron recognition and pre-spliceosome assembly is not tightly coupled to transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.