Evidence map›Paper›PMID 11266562›Full record

ArticleNucleic acids research2001

Highly expressed and alien genes of the Synechocystis genome.

J Mrázek, D Bhaya, A R Grossman, S Karlin

Open access · bronzeAbstract read
In one paragraph

Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
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  7. Review
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  16. Article
  17. Predicting gene expression level from relative codon usage bias: an application to Escherichia coli genome.DNA research : an international journal for rapid publication of reports on genes and genomes · 2009
    Article
  18. Barcodes for genomes and applications.BMC bioinformatics · 2008
    Article
  19. Article
  20. Distinctive features of large complex virus genomes and proteomes.Proceedings of the National Academy of Sciences of the United States of America · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

J MrázekDepartment of Mathematics, Stanford University, Stanford, CA 94305-2125, USA.
D Bhaya
A R Grossman
S Karlin
Stanford University · US

Funding

THEORY &APPLIED STUDIES IN EVOLUTIONARY GENETICSR01GM010452 · NIGMS · STANFORD UNIVERSITY · PI KARLIN, SAMUEL · 1985 to 2006
$2.1M
MOLECULAR SEQUENCE DATAR01HG000335 · NHGRI · STANFORD UNIVERSITY · PI KARLIN, SAMUEL · 1990 to 2001
$449k
NHGRI NIH HHS 5RO1HG00335-11NIGMS NIH HHS 5RO1GM10452-35NIGMS NIH HHS R01 GM010452
6 · The paper itself

Abstract

Comparisons of codon frequencies of genes to several gene classes are used to characterize highly expressed and alien genes on the SYNECHOCYSTIS: PCC6803 genome. The primary gene classes include the ensemble of all genes (average gene), ribosomal protein (RP) genes, translation processing factors (TF) and genes encoding chaperone/degradation proteins (CH). A gene is predicted highly expressed (PHX) if its codon usage is close to that of the RP/TF/CH standards but strongly deviant from the average gene. Putative alien (PA) genes are those for which codon usage is significantly different from all four classes of gene standards. In SYNECHOCYSTIS:, 380 genes were identified as PHX. The genes with the highest predicted expression levels include many that encode proteins vital for photosynthesis. Nearly all of the genes of the RP/TF/CH gene classes are PHX. The principal glycolysis enzymes, which may also function in CO(2) fixation, are PHX, while none of the genes encoding TCA cycle enzymes are PHX. The PA genes are mostly of unknown function or encode transposases. Several PA genes encode polypeptides that function in lipopolysaccharide biosynthesis. Both PHX and PA genes often form significant clusters (operons). The proteins encoded by PHX and PA genes are described with respect to functional classifications, their organization in the genome and their stoichiometry in multi-subunit complexes.

Indexed as

Gene ExpressionGenomeCodonCyanobacteriaOpen Reading FramesPeptide Elongation FactorsPhotosynthesisProtein BiosynthesisRibosomal ProteinsTranscription FactorsCodonPeptide Elongation FactorsRibosomal ProteinsTranscription Factors

Identifiers

PMID11266562
PMCPMC31270
OpenAlexW2100310722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.