ArticleThe Journal of cell biology2001
Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: Implications for cellular health and diseases.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Review
- Compound heterozygous variants of THG1L result in autosomal recessive cerebellar ataxia.Journal of human genetics · 2023Article
- Role of Lipids and Divalent Cations in Membrane Fusion Mediated by the Heptad Repeat Domain 1 of Mitofusin.Biomolecules · 2023Article
- The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria.Journal of cell science · 2023Article
- Article
- Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH.Acta pharmacologica Sinica · 2022Article
- Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening inmicroPublication biology · 2022Article
- Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm.Life (Basel, Switzerland) · 2021Review
- Mitofusin-2: A New Mediator of Pathological Cell Proliferation.Frontiers in cell and developmental biology · 2021Review
- Mitochondrial damage & lipid signaling in traumatic brain injury.Experimental neurology · 2020Review
- A Molecular Perspective on Mitochondrial Membrane Fusion: From the Key Players to Oligomerization and Tethering of Mitofusin.The Journal of membrane biology · 2019Review
- Mitochondria as central hub of the immune system.Redox biology · 2019Review
- Mitochondrial dynamics and mitophagy are necessary for proper invasive growth in rice blast.Molecular plant pathology · 2019Article
- Article
- Structural basis for membrane tethering by a bacterial dynamin-like pair.Nature communications · 2018Article
- Tetrahymena dynamin-related protein 6 self-assembles independent of membrane association.Journal of biosciences · 2018Article
- Recent insights into the structure and function of Mitofusins in mitochondrial fusion.F1000Research · 2018Review
- A membrane-inserted structural model of the yeast mitofusin Fzo1.Scientific reports · 2017Article
- Fusion, fission, and transport control asymmetric inheritance of mitochondria and protein aggregates.The Journal of cell biology · 2017Article
- An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation.eLife · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial membrane fusion is a process essential for the maintenance of the structural integrity of the organelle. Since mitochondria are bounded by a double membrane, they face the challenge of fusing four membranes in a coordinated manner. We provide evidence that this is achieved by coupling of the mitochondrial outer and inner membranes by the mitochondrial fusion machinery. Fzo1, the first known mediator of mitochondrial fusion, spans the outer membrane twice, exposing a short loop to the intermembrane space. The presence of the intermembrane space segment is required for the localization of Fzo1 in sites of tight contact between the mitochondrial outer and inner membranes. Mutations in the intermembrane space domain of yeast Fzo1 relieve the association with the inner membrane. This results in a loss of function of the protein in vivo. We propose that the mitochondrial fusion machinery forms membrane contact sites that mediate mitochondrial fusion. A fusion machinery that is in contact with both mitochondrial membranes appears to be functionally important for coordinated fusion of four mitochondrial membranes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.