ArticleThe Journal of cell biology2001
Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
90 citing papers in PubMed, 211 citations in OpenAlex.
- The molecular mechanisms and physiological roles of mitochondria dynamics inMicrobial cell (Graz, Austria) · 2025Review
- Mitochondrial-derived compartments are multilamellar domains that encase membrane cargo and cytosol.The Journal of cell biology · 2024Article
- Mitochondrial-Derived Compartments are Multilamellar Domains that Encase Membrane Cargo and Cytosol.bioRxiv : the preprint server for biology · 2023Article
- Synthetic negative genome screen of the GPN-loop GTPase NPA3 in Saccharomyces cerevisiae.Current genetics · 2022Article
- Pathways shaping the mitochondrial inner membrane.Open biology · 2021Review
- Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex.Nature communications · 2021Article
- New insights into the regulation of synaptic transmission and plasticity by the endoplasmic reticulum and its membrane contacts.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2021Review
- ER-mitochondria contacts promote mitochondrial-derived compartment biogenesis.The Journal of cell biology · 2020Article
- The Endoplasmic Reticulum-Mitochondria Encounter Structure Complex Coordinates Coenzyme Q Biosynthesis.Contact (Thousand Oaks (Ventura County, Calif.)) · 2019Article
- Article
- In Mitochondria ?-Actin Regulates mtDNA Transcription and Is Required for Mitochondrial Quality Control.iScience · 2018Article
- Visualizing multiple inter-organelle contact sites using the organelle-targeted split-GFP system.Scientific reports · 2018Article
- Crystal structures of Mmm1 and Mdm12-Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- ER-mitochondria tethering by PDZD8 regulates CaScience (New York, N.Y.) · 2017Article
- Article
- ER fatalities-The role of ER-mitochondrial contact sites in yeast life and death decisions.Mechanisms of ageing and development · 2017Review
- The Mitochondrial GTPase Gem1 Contributes to the Cell Wall Stress Response and Invasive Growth ofFrontiers in microbiology · 2017Article
- Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex.EMBO reports · 2016Article
- Lipid synthesis and membrane contact sites: a crossroads for cellular physiology.Journal of lipid research · 2016Review
- Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites.Molecular biology of the cell · 2016Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In the yeast Saccharomyces cerevisiae, mitochondria form a branched, tubular reticulum in the periphery of the cell. Mmm1p is required to maintain normal mitochondrial shape and in mmm1 mutants mitochondria form large, spherical organelles. To further explore Mmm1p function, we examined the localization of a Mmm1p-green fluorescent protein (GFP) fusion in living cells. We found that Mmm1p-GFP is located in small, punctate structures on the mitochondrial outer membrane, adjacent to a subset of matrix-localized mitochondrial DNA nucleoids. We also found that the temperature-sensitive mmm1-1 mutant was defective in transmission of mitochondrial DNA to daughter cells immediately after the shift to restrictive temperature. Normal mitochondrial nucleoid structure also collapsed at the nonpermissive temperature with similar kinetics. Moreover, we found that mitochondrial inner membrane structure is dramatically disorganized in mmm1 disruption strains. We propose that Mmm1p is part of a connection between the mitochondrial outer and inner membranes, anchoring mitochondrial DNA nucleoids in the matrix.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.