ArticleThe Journal of cell biology2001
Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- A theory of rapid evolutionary change explaining the de novo appearance of megakaryocytes and platelets in mammals.Journal of cell science · 2022Article
- Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway.Journal of assisted reproduction and genetics · 2021Article
- Quercetin suppresses lung cancer growth by targeting Aurora B kinase.Cancer medicine · 2016Article
- Article
- The aurora kinases in cell cycle and leukemia.Oncogene · 2015Review
- Article
- Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.Investigational new drugs · 2013Article
- Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation.Physiological genomics · 2012Article
- RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization.Nature communications · 2012Article
- The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent.Cell cycle (Georgetown, Tex.) · 2012Article
- Article
- Changing roles of aurora-B kinase in two life cycle stages of Trypanosoma brucei.Eukaryotic cell · 2006Article
- Differential requirements for survivin in hematopoietic cell development.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property.Molecular and cellular biology · 2005Article
- Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656.Blood · 2005Article
- Article
- Molecular control of megakaryopoiesis and thrombopoiesis.International journal of hematology · 2002Review
- The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis.Molecular biology of the cell · 2002Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the late phase of megakaryopoiesis, megakaryocytes undergo polyploidization, which is characterized by DNA duplication without concomitant cell division. However, it remains unknown by which mechanisms this process occurs. AIM-1 and STK15 belong to the Aurora/increase-in-ploidy (Ipl)1 serine/threonine kinase family and play key roles in mitosis. In a human interleukin-3-dependent cell line, F-36P, the expressions of AIM-1 and STK15 mRNA were specifically observed at G2/M phase of the cell cycle during proliferation. In contrast, the expressions of AIM-1 and STK15 were continuously repressed during megakaryocytic polyploidization of human erythro/megakaryocytic cell lines (F-36P, K562, and CMK) treated with thrombopoietin, activated ras (H-ras(G12V)), or phorbol ester. Furthermore, their expressions were suppressed during thrombopoietin-induced polyploidization of normal human megakaryocytes. Activation of AIM-1 by the induced expression of AIM-1(wild-type) canceled TPA-induced polyploidization of K562 cells significantly, whereas that of STK15 did not. Moreover, suppression of AIM-1 by the induced expression of AIM-1 (K/R, dominant-negative type) led to polyploidization in 25% of K562 cells, whereas STK15(K/R) showed no effect. Also, the induced expression of AIM-1(K/R) in CMK cells provoked polyploidization up to 32N. These results suggested that downregulation of AIM-1 at M phase may be involved in abortive mitosis and polyploid formation of megakaryocytes.
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