ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
159 citing papers in PubMed, 446 citations in OpenAlex.
- Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial.Psychopharmacology · 2025Trial
- Oxytocin differentially modulates pavlovian cue and context fear acquisition.Social cognitive and affective neuroscience · 2017Trial
- Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample.Psychopharmacology · 2013Trial
- Intranasal oxytocin blocks alcohol withdrawal in human subjects.Alcoholism, clinical and experimental research · 2013Trial
- Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Trial
- Protocol for an experimental investigation of the roles of oxytocin and social support in neuroendocrine, cardiovascular, and subjective responses to stress across age and gender.BMC public health · 2009Trial
- Effects of oxytocin and prosocial behavior on brain responses to direct and vicariously experienced pain.Emotion (Washington, D.C.) · 2008Trial
- Oxytocin promotes socially triggered cataplexy.Nature neuroscience · 2026Article
- Article
- Prefrontal oxytocin receptor positive cells mediate stress-induced anxiety in tuberous sclerosis complex.Communications biology · 2025Article
- Oxytocin as a treatment for alcohol use disorder and heavy drinking: A narrative review.Experimental and clinical psychopharmacology · 2024Review
- Female zebra finches are more vulnerable to social isolation stress than males: Involvement of the nonapeptide system.Zoological research · 2024Article
- The Role of Oxytocin and Vasopressin in People with Borderline Personality Disorder: A Closer Look at Adolescents.International journal of molecular sciences · 2024Review
- The central oxytocinergic system of the prairie vole.Brain structure & function · 2024Article
- Modulating reward and aversion: Insights into addiction from the paraventricular nucleus.CNS neuroscience & therapeutics · 2024Review
- µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice.Translational psychiatry · 2024Article
- Beyond fur color: differences in socio-emotional behavior and the oxytocin system between male BL6 and CD1 mice in adolescence and adulthood.Frontiers in neuroscience · 2024Article
- Neurobiological traces of grief: Examining the impact of offspring loss after birth on rat mothers' brain and stress-coping behavior in the first week postpartum.Neuroscience applied · 2024Article
- Neuromodulation of safety and surprise in the early stages of infant development: affective homeostatic regulation in bodily and mental functions.Frontiers in psychology · 2024Review
99 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The oxytocin receptor (OTR) is differentially expressed in the CNS. Because there are multiple mechanisms by which the OTR can be transcriptionally induced, we hypothesized that differences in OTR expression may be explained by activation of distinct signal transduction pathways and may be critical for the control of anxiety and sex behaviors. To determine the regulation and functional significance of this expression, we infused female rats with modifiers of protein kinases before assaying for behavior and oxytocin receptor binding. In the ventromedial nucleus of the hypothalamus (VMH), estrogen-dependent induction of oxytocin receptors required protein kinase C activation, and oxytocin infused here promoted female sex behavior but had no effect on anxiety. In contrast, dopamine controlled tonic oxytocin receptor expression in the central nucleus of the amygdala (cAmyg) through activation of protein kinase A, and oxytocin infused here was anxiolytic but had no effect on female sex behavior. Therefore, we have identified brain region-specific regulation of the OTR in the VMH and cAmyg. Distinct signal transduction pathways regulating receptor expression and binding in each brain region may mediate in part the ability of oxytocin to exert these differential behavioral effects.
Indexed as
Identifiers
11264328PMC6762393W1948173875What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.