ArticleBritish journal of pharmacology2001
Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 62 citations in OpenAlex.
- Agonist-selective activation of individual G-proteins by muscarinic receptors.Scientific reports · 2024Article
- Imaging of GαPharmaceutics · 2022Article
- Melatonin-Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions.Antioxidants (Basel, Switzerland) · 2022Review
- GNA14's interaction with RACK1 inhibits hepatocellular carcinoma progression through reducing MAPK/JNK and PI3K/AKT signaling pathway.Carcinogenesis · 2021Article
- The GPR17 Receptor-A Promising Goal for Therapy and a Potential Marker of the Neurodegenerative Process in Multiple Sclerosis.International journal of molecular sciences · 2020Review
- Melatonin and Hippo Pathway: Is There Existing Cross-Talk?International journal of molecular sciences · 2017Article
- Deep sequencing of the transcriptome in the anterior pituitary of heifers before and after ovulation.The Journal of veterinary medical science · 2017Article
- Molecular Pharmacology of δ-Opioid Receptors.Pharmacological reviews · 2016Review
- A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.EMBO reports · 2016Article
- Gα14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons.Journal of neurophysiology · 2016Article
- The experimental power of FR900359 to study Gq-regulated biological processes.Nature communications · 2015Article
- Role for engagement of β-arrestin2 by the transactivated EGFR in agonist-specific regulation of δ receptor activation of ERK1/2.British journal of pharmacology · 2015Article
- An intact helical domain is required for Gα14 to stimulate phospholipase Cβ.BMC structural biology · 2015Article
- Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.World journal of gastroenterology · 2014Article
- Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms.Cell communication and signaling : CCS · 2013Article
- Distribution, function and physiological role of melatonin in the lower gut.World journal of gastroenterology · 2011Review
- Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Inhibitory effect of somatostatin-14 on L-type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calcium.Journal of neurophysiology · 2009Article
- Dopamine receptor-coupling defect in hypertension.Current hypertension reports · 2002Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The bovine Galpha(14) is a member of the G(q) subfamily of G proteins that can regulate phospholipase Cbeta isoforms but the extent to which Galpha(14) recognizes different receptor classes is not known. 2. Galpha(14) was cotransfected with a variety of receptors in COS-7 cells, and agonist-induced stimulation of phospholipase C was then measured. 3. Activation of the type 2 but not type 1 somatostatin receptor in cells coexpressing Galpha(14) stimulated the accumulation of inositol phosphates; functional expression of both subtypes of somatostatin receptors was determined by the ability of somatostatin to inhibit cyclic AMP accumulation. 4. Among the three opioid receptors (mu, delta, and kappa), only the delta receptor was capable of stimulating IP formation when coexpressed with Galpha(14) in COS-7 cells. 5. A panel of G(i)- and G(s)-linked receptors was screened for their ability to stimulate IP accumulation via Galpha(14). The adenosine A(1), complement C5a, dopamine D(1), D(2) and D(5), formyl peptide, luteinizing hormone, secretin, and the three subtypes of melatonin (mt1, MT2, and Xenopus) receptors were all incapable of activating Galpha(14), while the alpha(2)- and beta(2)-adrenoceptors were able to do so. 6. Galpha(14)-mediated stimulation of phospholipase Cbeta was agonist dose-dependent. These data demonstrate that although Galpha(14) can interact with different classes of receptors, it is much less promiscuous than Galpha(15) or Galpha(16).
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