ArticleJournal of neuro-oncology2000
Cerebral metastases as first symptom of cancer: a clinico-pathologic study.
Article in Journal of neuro-oncology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Symptomatic diagnosis of cancer of the brain and central nervous system in primary care: a systematic review.Family practice · 2015Pooled it
- Incidence of intra-axial brain metastases in Eastern Finland.Journal of neuro-oncology · 2026Article
- Treatment decisions for intermediate-sized brain metastases in or near the motor cortex among the neuro-oncology community.Brain & spine · 2025Article
- Metastatic Lesions of the Brain and Spine.Advances in experimental medicine and biology · 2023Article
- Differentiation of Glioblastoma and Brain Metastases by MRI-Based Oxygen Metabolomic Radiomics and Deep Learning.Metabolites · 2022Article
- Evaluation of the impact of pre-operative stereotactic radiotherapy on the acute changes in histopathologic and immune marker profiles of brain metastases.Scientific reports · 2022Article
- Physiological MRI Biomarkers in the Differentiation Between Glioblastomas and Solitary Brain Metastases.Molecular imaging and biology · 2021Article
- Brain Metastasis from Unknown Primary Tumour: Moving from Old Retrospective Studies to Clinical Trials on Targeted Agents.Cancers · 2020Review
- Comparison of Intraoperative Ultrasound B-Mode and Strain Elastography for the Differentiation of Glioblastomas From Solitary Brain Metastases. An Automated Deep Learning Approach for Image Analysis.Frontiers in oncology · 2020Article
- Brain metastases as first manifestation of advanced cancer: exploratory analysis of 459 patients at a tertiary care center.Clinical & experimental metastasis · 2018Article
- Esophageal cancer presenting as a brain metastasis: A case report.Oncology letters · 2013Article
- Brain metastases as the first symptom of lung cancer: a clinical study from an Asian medical center.Journal of cancer research and clinical oncology · 2013Article
- Gliadel for brain metastasis.Surgical neurology international · 2013Article
- Metastasis of occult prostatic carcinoma to the sphenoid sinus: report of a rare case and a review of the literature.Head and neck pathology · 2012Review
- Epidemiology of brain metastases.Current oncology reports · 2012Article
- A study of patients with brain metastases as the initial manifestation of their systemic cancer in a Chinese population.Journal of neuro-oncology · 2011Article
- The price of diagnosis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2008Article
- Multifocal symptomatic intracerebral metastases as the first manifestation of prostatic carcinoma: a report and literature review.International urology and nephrology · 2008Review
- Clinical features of primary brain tumours: a case-control study using electronic primary care records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2007Article
- Surgical treatment for brain metastases: prognostic factors and survival in 177 patients.Neurosurgical review · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symptomatic brain metastases of carcinomas in patients without a previously diagnosed malignancy are frequent in neurosurgical series. Such tumors often lack distinctive morphological characteristics so that the routine histological examination can be unsuccessful in identifying the site of origin. Objectives of the present study were to evaluate the frequency of brain metastases as the only manifestation of an unknown primary cancer by the retrospective analysis of a series of consecutively operated single cerebral metastases; to verify the efficacy of clinical investigations in detecting the site of origin; to investigate whether the primary site can be identified by the immunohistochemical study of the neurosurgical specimens. Antibodies to the following antigens were used: carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19.9, CA 125, BCA-225, cytokeratin 20, PSA, HMB-45. Out of 181 patients operated for single cerebral metastasis of carcinoma, 99 (54.7%) were in patients without any previously diagnosed systemic neoplasm. In 26.7% the primary remained undiagnosed after clinical investigations, in 9 cases even at autopsy. PSA and HMB45 antibodies specifically identified metastases from prostate carcinomas and skin melanomas, respectively. No other specific immunophenotype was identified; the immunoreactivity of the single cases was more or less suggestive for a primary site. Precocious metastases of lung carcinomas expressed CEA more frequently than late metastases. It has been hypothesized that CEA plays some role as a contact mediating device. CEA expression can have some link with the tendency to metastasize precociously to the brain. No major difference of p53 and k-ras expression has been found in precocious versus late brain metastases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.