ArticleGlycoconjugate journal2000
Expression of H type 1 antigen of ABO histo-blood group in normal colon and aberrant expressions of H type 2 and H type 3/4 antigens in colon cancer.
Article in Glycoconjugate journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Relationship between ABO blood group and lymph node metastasis in colon cancer: a retrospective cohort study.World journal of surgical oncology · 2026Observational
- Human ABO Blood Groups and Their Associations with Different Diseases.BioMed research international · 2021Review
- Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype.Cellular and molecular life sciences : CMLS · 2021Article
- Can theNutrients · 2020Article
- Terminal fucose mediates progression of human cholangiocarcinoma through EGF/EGFR activation and the Akt/Erk signaling pathway.Scientific reports · 2019Article
- Blood type biochemistry and human disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Association of Ulcerative Colitis with FUT2 and FUT3 Polymorphisms in Patients from Southeast China.PloS one · 2016Article
- Sugar-binding proteins from fish: selection of high affinity "lambodies" that recognize biomedically relevant glycans.ACS chemical biology · 2013Article
- Association of type-O blood with neuroendocrine tumors in multiple endocrine neoplasia type 1.The Journal of clinical endocrinology and metabolism · 2013Article
- Association between the ABO blood group and the human intestinal microbiota composition.BMC microbiology · 2012Article
- Association of type O blood with pancreatic neuroendocrine tumors in Von Hippel-Lindau syndrome.Annals of surgical oncology · 2012Article
- Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease.Journal of gastroenterology · 2011Article
- Higher frequency of secretor phenotype in O blood group - its benefits in prevention and/or treatment of some diseases.International journal of nanomedicine · 2010Article
- MAb L9E10 to blood group H2 antigen binds to colon cancer stem cells and inhibits tumor cell migration and invasion.Hybridoma (2005) · 2010Article
- Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cells.Virchows Archiv : an international journal of pathology · 2010Article
- Increased expression of a Myc target gene Mina53 in human colon cancer.The American journal of pathology · 2004Article
- Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates.Revista brasileira de hematologia e hemoterapiaArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have immunohistochemically examined the distribution of the H antigens of type 1, type 2 and type 3/4 chains of the ABO(H) histo-blood group system in human normal colon and in colon cancer using three monoclonal antibodies specific for each of the H type 1/2, H type 2, and the H type 3/4 chain. We unexpectedly found that mucosa of the normal colon from secretors but not that from nonsecretors expressed only H type 1 and did not express H type 2 or H type 3/4. The H type 1 was expressed in goblet cells. Positive goblet cells expressing H type 1 were decreased in number progressively from the proximal colon to the rectum. In tumors, 4 (57%) of 7 cancer tissues of the proximal colon from secretors expressed no H type 1, whereas all 8 cancer tissues of the distal colon from secretors expressed H type 1. The aberrant expressions of H type 2 and H type 3/4 (47 and 67%, respectively) were found in cancer tissues from both the proximal and the distal colon. Tumors from nonsecretors did not express any H antigens. Our results suggested that the expression of H type 1 in the normal colon and the aberrant expressions of H type 2 and H type 3/4 in colon cancer tissues were regulated by FUT2-encoded Se type alpha(1,2)fucosyltransferase. However, UEA-I-positive substance(s) rather than H type 2 were uniquely expressed throughout the normal colon and in colon cancers from both secretors and nonsecretors.
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