ArticleProceedings of the National Academy of Sciences of the United States of America2001
The Sm domain is an ancient RNA-binding motif with oligo(U) specificity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61 citing papers in PubMed, 128 citations in OpenAlex.
- A novel NLP-based method and algorithm to discover RNA-binding protein (RBP) motifs, contexts, binding preferences, and interactions.RNA (New York, N.Y.) · 2026Article
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- Remodeling of RNA-binding proteome and RNA-mediated regulation as a new layer of control of sporulation.mSystems · 2025Article
- Protein Fold Usages in Ribosomes: Another Glance to the Past.International journal of molecular sciences · 2024Article
- Analysis of Lsm Protein-Mediated Regulation in the HaloarchaeonInternational journal of molecular sciences · 2024Article
- Splicing-mediated activation of SHAGGY-like kinases underpinning carbon partitioning in Arabidopsis seeds.The Plant cell · 2022Article
- Review
- Exomeres and Supermeres: monolithic or diverse?Journal of extracellular biology · 2022Article
- Fold Evolution before LUCA: Common Ancestry of SH3 Domains and OB Domains.Molecular biology and evolution · 2021Article
- Hfq chaperone brings speed dating to bacterial sRNA.Wiley interdisciplinary reviews. RNA · 2018Review
- The SmAP2 RNA binding motif in the 3'UTR affects mRNA stability in the crenarchaeum Sulfolobus solfataricus.Nucleic acids research · 2017Article
- The role of Hfq in regulation of lipA expression in Pseudomonas protegens Pf-5.Scientific reports · 2017Article
- The SmAP1/2 proteins of the crenarchaeon Sulfolobus solfataricus interact with the exosome and stimulate A-rich tailing of transcripts.Nucleic acids research · 2017Article
- ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics.PLoS genetics · 2016Article
- Gemin5 Binds to the Survival Motor Neuron mRNA to Regulate SMN Expression.The Journal of biological chemistry · 2015Article
- Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.PLoS genetics · 2015Article
- U1A regulates 3' processing of the survival motor neuron mRNA.The Journal of biological chemistry · 2014Article
- FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sm and Sm-like proteins are members of a family of small proteins that is widespread throughout eukaryotic kingdoms. These proteins form heteromers with one another and bind, as heteromeric complexes, to various RNAs, recognizing primarily short U-rich stretches. Interestingly, completion of several genome projects revealed that archaea also contain genes that may encode Sm-like proteins. Herein, we studied the properties of one Sm-like protein derived from the archaebacterium Archaeoglobus fulgidus and overexpressed in Escherichia coli. This single small protein closely reflects the properties of an Sm or Sm-like protein heteromer. It binds to RNA with a high specificity for oligo(U), and assembles onto the RNA to form a complex that exhibits, as judged by electron microscopy, a ring-like structure similar to the ones observed with the Sm core ribonucleoprotein and the like Sm (LSm) protein heteromer. Importantly, multivariate statistical analysis of negative-stain electron-microscopic images revealed a sevenfold symmetry for the observed ring structure, indicating that the proteins form a homoheptamer. These results support the structural model of the Sm proteins derived from crystallographic studies on Sm heterodimers and demonstrate that the Sm protein family evolved from a single ancestor that was present before the eukaryotic and archaeal kingdoms separated.
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