ArticleProceedings of the National Academy of Sciences of the United States of America2001
Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 104 citations in OpenAlex.
- A multiscale cell-based model of tumor growth for chemotherapy assessment and tumor-targeted therapy through a 3D computational approach.Cell proliferation · 2022Article
- Recombinant anthrax lethal toxin inhibits cell motility and invasion in breast cancer cells through the dysregulation of Rho GTPases.Oncology letters · 2021Article
- The Anthrax Toxin Receptor 1 (ANTXR1) Is Enriched in Pancreatic Cancer Stem Cells Derived from Primary Tumor Cultures.Stem cells international · 2019Article
- The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals.Toxins · 2017Review
- Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgrafts.International journal of oncology · 2015Article
- Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.Oncogene · 2014Article
- Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen.Molecular oncology · 2013Article
- The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells.The Journal of biological chemistry · 2012Article
- Article
- MEK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 melanoma cells.PloS one · 2011Article
- The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton.Biochimica et biophysica acta · 2011Article
- Article
- Targeting the anthrax receptors, TEM-8 and CMG-2, for anti-angiogenic therapy.Frontiers in bioscience (Landmark edition) · 2011Review
- Consequences and utility of the zinc-dependent metalloprotease activity of anthrax lethal toxin.Toxins · 2010Review
- Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma.Molecular cancer therapeutics · 2010Article
- Cellular and systemic effects of anthrax lethal toxin and edema toxin.Molecular aspects of medicine · 2009Review
- Article
- Host-derived tumor endothelial marker 8 promotes the growth of melanoma.Cancer research · 2009Article
- Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis.Molecular cancer research : MCR · 2009Article
- Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis.BMC immunology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Lethal factor is a protease, one component of Bacillus anthracis exotoxin, which cleaves many of the mitogen-activated protein kinase kinases (MEKs). Given the importance of MEK signaling in tumorigenesis, we assessed the effects of anthrax lethal toxin (LeTx) on tumor cells. LeTx was very effective in inhibiting mitogen-activated protein kinase activation in V12 H-ras-transformed NIH 3T3 cells. In vitro, treatment of transformed cells with LeTx caused them to revert to a nontransformed morphology, and inhibited their abilities to form colonies in soft agar and to invade Matrigel without markedly affecting cell proliferation. In vivo, LeTx inhibited growth of ras-transformed cells implanted in athymic nude mice (in some cases causing tumor regression) at concentrations that caused no apparent animal toxicity. Unexpectedly, LeTx also greatly decreased tumor neovascularization. These results demonstrate that LeTx potently inhibits ras-mediated tumor growth and is a potential antitumor therapeutic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.