ArticleMolecular and cellular biology2001
Functional analysis of mouse C-terminal kinesin motor KifC2.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Kinesins in Mammalian Spermatogenesis and Germ Cell Transport.Frontiers in cell and developmental biology · 2022Review
- Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.Cancer science · 2020Article
- Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Disrupting Foxh1-Groucho interaction reveals robustness of nodal-based embryonic patterning.Mechanisms of development · 2015Article
- Recycling of kinesin-1 motors by diffusion after transport.PloS one · 2013Article
- Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles.Journal of cell science · 2011Article
- Expression of kinesin superfamily genes in cultured hippocampal neurons.Cytoskeleton (Hoboken, N.J.) · 2010Article
- Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver.Molecular biology of the cell · 2007Article
- The axonal transport of mitochondria.Journal of cell science · 2005Review
- Kinesin superfamily proteins (KIFs) in the mouse transcriptome.Genome research · 2003Article
- A novel sorting motif in the glutamate transporter excitatory amino acid transporter 3 directs its targeting in Madin-Darby canine kidney cells and hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.Genes & development · 2001Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins of the kinesin superfamily define a class of microtubule-dependent motors that play crucial roles in cell division and intracellular transport. In the mouse, several kinesin motors have been characterized and are suggested to play roles in axonal and/or dendritic transport. One such kinesin is KifC2. Sequence and secondary structure analysis revealed that KifC2 is a member of the C-terminal motor family. Northern and Western blot analyses indicated that KifC2 is specifically expressed in both the central and peripheral nervous systems. The cellular locations of the KifC2 proteins were found to be mainly in neural cell bodies and dendrites but also in axons. To understand the in vivo function of the KifC2 gene, we used homologous recombination in embryonic stem cells to construct knockout mouse strains for the KifC2 gene. Homozygous KifC2 mutants were viable and reproduced normally, and their development was apparently normal. These results suggest that KifC2 is dispensable for normal neural development and behavior in the mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.