ArticleMolecular and cellular biology2001
Establishment and maintenance of DNA methylation patterns in mouse Ndn: implications for maintenance of imprinting in target genes of the imprinting center.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Methylation is maintained specifically at imprinting control regions but not other DMRs associated with imprinted genes in mice bearing a mutation in theFrontiers in cell and developmental biology · 2023Article
- Hemimethylation of CpG dyads is characteristic of secondary DMRs associated with imprinted loci and correlates with 5-hydroxymethylcytosine at paternally methylated sequences.Epigenetics & chromatin · 2019Article
- Transgenic mice with a tandem duplication of the Necdin gene overexpress Necdin.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm.Environmental epigenetics · 2017Article
- Asymmetric DNA methylation of CpG dyads is a feature of secondary DMRs associated with theEpigenetics & chromatin · 2017Article
- Epigenetic alteration of imprinted genes during neural differentiation of germline-derived pluripotent stem cells.Epigenetics · 2016Article
- Analysis of DNA methylation acquisition at the imprinted Dlk1 locus reveals asymmetry at CpG dyads.Epigenetics & chromatin · 2014Article
- Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.Molecular and cellular biology · 2013Article
- Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation.Epigenetics & chromatin · 2013Article
- Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences.PLoS genetics · 2013Article
- Mechanisms of activation of the paternally expressed genes by the Prader-Willi imprinting center in the Prader-Willi/Angelman syndromes domains.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Temporal and developmental requirements for the Prader-Willi imprinting center.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- An unexpected function of the Prader-Willi syndrome imprinting center in maternal imprinting in mice.PloS one · 2012Article
- Establishment of paternal allele-specific DNA methylation at the imprinted mouse Gtl2 locus.Epigenetics · 2011Article
- Timing is everything: the when and how of environmentally induced changes in the epigenome of animals.Epigenetics · 2011Review
- Monoallelic expression of multiple genes in the CNS.PloS one · 2007Article
- Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice.Molecular and cellular biology · 2006Article
- Tissue-specific and imprinted epigenetic modifications of the human NDN gene.Nucleic acids research · 2004Article
- Influence of in vitro manipulation on the stability of methylation patterns in the Snurf/Snrpn-imprinting region in mouse embryonic stem cells.Nucleic acids research · 2004Article
- Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region.Genome research · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ndn is located on chromosome 7C, an imprinted region of the mouse genome. Imprinting of Ndn and adjacent paternally expressed genes is regulated by a regional imprinting control element known as the imprinting center (IC). An IC also controls imprint resetting of target genes in the region of conserved synteny on human chromosome 15q11-q13, which is deleted or rearranged in the neurodevelopmental disorder Prader-Willi syndrome. Epigenetic modifications such as DNA methylation, which occur in gametes and can be stably propagated, are presumed to establish and maintain the imprint in target genes of the IC. While most DNA becomes substantially demethylated by the blastocyst stage, some imprinted genes have regions that escape global demethylation and may maintain the imprint. We have now analyzed the methylation of 39 CpG dinucleotide sequences in the 5' end of Ndn by sodium bisulfite sequencing in gametes and in preimplantation and adult tissues. While sperm DNA is completely unmethylated across this region, oocyte DNA is partially methylated. A distinctive but unstable maternal methylation pattern persists until the morula stage and is lost in the blastocyst stage, where low levels of methylation are present on most DNA strands of either parental origin. The methylation pattern is then substantially remodeled, and fewer than half of maternally derived DNA strands in adult brain resemble the oocyte pattern. We postulate that for Ndn, DNA methylation may initially preserve a gametic imprint during preimplantation development, but other epigenetic events may maintain the imprint later in embryonic development.
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