ArticleMolecular and cellular biology2001
Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- The subunit composition of the mammalian Mediator complex is not conserved in all vertebrates: Insights from evolutionary plasticity of fish genomes.Protein science : a publication of the Protein Society · 2026Article
- Article
- Evolution of disorder in Mediator complex and its functional relevance.Nucleic acids research · 2016Article
- Disordered proteinaceous machines.Chemical reviews · 2014Review
- Rearrangements of 2.5 kilobases of noncoding DNA from the Drosophila even-skipped locus define predictive rules of genomic cis-regulatory logic.PLoS genetics · 2013Article
- Article
- The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress.Plant physiology · 2011Article
- Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription.Genes & development · 2011Article
- Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster.BMC genomics · 2011Article
- Origins and activity of the Mediator complex.Seminars in cell & developmental biology · 2011Review
- Identical functional organization of nonpolytene and polytene chromosomes in Drosophila melanogaster.PloS one · 2011Article
- Identification, structure, and functional requirement of the Mediator submodule Med7N/31.The EMBO journal · 2009Article
- Malleable machines in transcription regulation: the mediator complex.PLoS computational biology · 2008Article
- Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex.Nucleic acids research · 2008Article
- A subunit of the mediator complex regulates vertebrate neuronal development.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- The mediator of RNA polymerase II.Chromosoma · 2005Review
- Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.Molecular and cellular biology · 2004Article
- MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- A high resolution protein interaction map of the yeast Mediator complex.Nucleic acids research · 2004Article
- Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis.Genetics · 2003Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To decipher the mechanistic roles of Mediator proteins in regulating developmental specific gene expression and compare them to those of TATA-binding protein (TBP)-associated factors (TAFs), we isolated and analyzed a multiprotein complex containing Drosophila Mediator (dMediator) homologs. dMediator interacts with several sequence-specific transcription factors and basal transcription machinery and is critical for activated transcription in response to diverse transcriptional activators. The requirement for dMediator did not depend on a specific core promoter organization. By contrast, TAFs are preferentially utilized by promoters having a specific core element organization. Therefore, Mediator proteins are suggested to act as a pivotal coactivator that integrates promoter-specific activation signals to the basal transcription machinery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.