ArticleMolecular and cellular biology2001
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed, 152 citations in OpenAlex.
- Epigenetic regulation of transgenes.Journal of biotechnology · 2026Review
- TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathway.Cell death & disease · 2024Article
- The interactions between PML nuclear bodies and small and medium size DNA viruses.Virology journal · 2023Review
- Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs.The EMBO journal · 2023Article
- Promyelocytic leukemia protein targets MK2 to promote cytotoxicity.EMBO reports · 2021Article
- ZNF451 stabilizes TWIST2 through SUMOylation and promotes epithelial-mesenchymal transition.American journal of cancer research · 2021Article
- A Tale of Usurpation and Subversion: SUMO-Dependent Integrity of Promyelocytic Leukemia Nuclear Bodies at the Crossroad of Infection and Immunity.Frontiers in cell and developmental biology · 2021Review
- Role of ND10 nuclear bodies in the chromatin repression of HSV-1.Virology journal · 2016Review
- Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus.PLoS pathogens · 2015Article
- Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.Clinical epigenetics · 2015Article
- The function, regulation and therapeutic implications of the tumor suppressor protein, PML.Cell & bioscience · 2015Review
- PML-mediated signaling and its role in cancer stem cells.Oncogene · 2014Review
- Systematic analysis of time-series gene expression data on tumor cell-selective apoptotic responses to HDAC inhibitors.Computational and mathematical methods in medicine · 2014Article
- Review
- HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses.Cell death & disease · 2013Article
- Cytoplasmic localization of PML particles in laminopathies.Histochemistry and cell biology · 2013Article
- Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection.PLoS pathogens · 2012Article
- Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL.Leukemia · 2012Article
- MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs.Cell death and differentiation · 2012Article
- PML regulates PER2 nuclear localization and circadian function.The EMBO journal · 2012Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The growth suppressor promyelocytic leukemia protein (PML) is disrupted by the chromosomal translocation t(15;17) in acute promyelocytic leukemia (APL). PML plays a key role in multiple pathways of apoptosis and regulates cell cycle progression. The present study demonstrates that PML represses transcription by functionally and physically interacting with histone deacetylase (HDAC). Transcriptional repression mediated by PML can be inhibited by trichostatin A, a specific inhibitor of HDAC. PML coimmunoprecipitates a significant level of HDAC activity in several cell lines. PML is associated with HDAC in vivo and directly interacts with HDAC in vitro. The fusion protein PML-RARalpha encoded by the t(15;17) breakpoint interacts with HDAC poorly. PML interacts with all three isoforms of HDAC through specific domains, and its expression deacetylates histone H3 in vivo. Together, the results of our study show that PML modulates histone deacetylation and that loss of this function in APL alters chromatin remodeling and gene expression. This event may contribute to the development of leukemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.