ArticleBiophysical journal2001
Predicted profiles of ion concentrations in olfactory cilia in the steady state.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Adaptive integrate-and-fire model reproduces the dynamics of olfactory receptor neuron responses in a moth.Journal of the Royal Society, Interface · 2019Article
- CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Electrical Signaling in Motile and Primary Cilia.Bioscience · 2014Article
- The influence of Ca²⁺ buffers on free [Ca²⁺] fluctuations and the effective volume of Ca²⁺ microdomains.Biophysical journal · 2014Article
- Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.PloS one · 2014Article
- Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels.The Journal of general physiology · 2013Article
- Article
- Ca2+-activated Cl− currents are dispensable for olfaction.Nature neuroscience · 2011Article
- System identification of Drosophila olfactory sensory neurons.Journal of computational neuroscience · 2011Article
- Calcium activates a chloride conductance likely involved in olfactory receptor neuron repolarization in the moth Spodoptera littoralis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia.The Journal of general physiology · 2010Article
- Computational model of the insect pheromone transduction cascade.PLoS computational biology · 2009Article
- Article
- Identification of Cl(Ca) channel distributions in olfactory cilia.Mathematical methods in the applied sciences · 2008Article
- Olfactory marker protein modulates the cAMP kinetics of the odour-induced response in cilia of mouse olfactory receptor neurons.The Journal of physiology · 2007Article
- Mechanisms of neuronal chloride accumulation in intact mouse olfactory epithelium.The Journal of physiology · 2007Article
- The effect of external sodium concentration on sodium-calcium exchange in frog olfactory receptor cells.The Journal of physiology · 2007Article
- Clustering of cyclic-nucleotide-gated channels in olfactory cilia.Biophysical journal · 2006Article
- Numerical Approximation of Solutions of a Nonlinear Inverse Problem Arising in Olfaction Experimentation.Mathematical and computer modelling · 2006Article
- Model of calcium oscillations due to negative feedback in olfactory cilia.Biophysical journal · 2006Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of ciliary geometry for transduction events was explored by numerical simulation. The changes in intraciliary ion concentrations, suspected to occur during transduction, could thus be estimated. The case of a single excised cilium, having a uniform distribution of membrane channels, voltage clamped to -80 mV, was especially investigated. The axial profile of membrane voltage was that of a leaky cable. The Ca(2+) concentration profile tended to show a maximum in proximal segments, due to a preponderance of Ca(2+) inflow over Ca(2+) export at those locations. The local increase in Ca(2+) concentration activated Cl(-) channels. The resulting current caused a local drop in Cl(-) concentration, especially at the tip of the cilium and in distal segments, accompanied by a drop in ciliary K(+) concentration. In consequence, the membrane Cl(-) current was low in distal segments but stronger in proximal segments, where resupply was sufficient. The model predicts that the Cl(-) depletion will codetermine the time course of the receptor potential or current and the ciliary stimulus-response curve. In conclusion, when modeling with transduction elements presently known to participate, the ciliary geometry has large effects on ion distributions and transduction currents because ciliary ion transport is limited by axial electrodiffusion.
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