ArticleEMBO reports2001
An activation-independent role of transcription factors in insulator function.
Article in EMBO reports, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed, 81 citations in OpenAlex.
- Sequence and chemical specificity define the functional landscape of intrinsically disordered regions.Nature cell biology · 2026Article
- Massively parallel characterization of insulator activity across the genome.Nature communications · 2024Article
- Yeast heterochromatin stably silences only weak regulatory elements by altering burst duration.Cell reports · 2024Article
- Yeast Heterochromatin Only Stably Silences Weak Regulatory Elements by Altering Burst Duration.bioRxiv : the preprint server for biology · 2023Article
- Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability.Cell discovery · 2023Article
- SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing.Nature communications · 2022Article
- Partners in crime: Tbf1 and Vid22 promote expansions of long human telomeric repeats at an interstitial chromosome position in yeast.PNAS nexus · 2022Article
- StableProceedings of the National Academy of Sciences of the United States of America · 2016Article
- The highly expressed methionine synthase gene of Neurospora crassa is positively regulated by its proximal heterochromatic region.Nucleic acids research · 2014Article
- Epigenetics in Saccharomyces cerevisiae.Cold Spring Harbor perspectives in biology · 2013Review
- A compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription.PLoS genetics · 2013Article
- Nuclear Factor I genomic binding associates with chromatin boundaries.BMC genomics · 2013Article
- Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends.The EMBO journal · 2013Article
- A protosilencer of subtelomeric gene expression in Candida glabrata with unique properties.Genetics · 2012Article
- Nuclear factor I revealed as family of promoter binding transcription activators.BMC genomics · 2011Article
- Environment-responsive transcription factors bind subtelomeric elements and regulate gene silencing.Molecular systems biology · 2011Article
- Article
- Spatial epigenetic control of mono- and bistable gene expression.PLoS biology · 2010Article
- Loss of the insulator protein CTCF during nematode evolution.BMC molecular biology · 2009Article
- Transcription factor CTF1 acts as a chromatin domain boundary that shields human telomeric genes from silencing.Molecular and cellular biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromatin insulators are defined as transcriptionally neutral elements that prevent negative or positive influence from extending across chromatin to a promoter. Here we show that yeast subtelomeric anti-silencing regions behave as boundaries to telomere-driven silencing and also allow discontinuous propagation of silent chromatin. These two facets of insulator activity, boundary and silencing discontinuity, can be recapitulated by tethering various transcription activation domains to tandem sites on DNA. Importantly, we show that these insulator activities do not involve direct transcriptional activation of the reporter promoter. These findings predict that certain promoters behave as insulators and partition genomes in functionally independent domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.