ArticleEMBO reports2000
DNA motif associated with meiotic double-strand break regions in Saccharomyces cerevisiae.
Article in EMBO reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- The consequences of sequence erosion in the evolution of recombination hotspots.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- DNA sequence-mediated, evolutionarily rapid redistribution of meiotic recombination hotspots.Genetics · 2011Article
- Evolution of the nuclear ribosomal DNA intergenic spacer in four species of the Daphnia pulex complex.BMC genetics · 2011Article
- Mapping meiotic single-strand DNA reveals a new landscape of DNA double-strand breaks in Saccharomyces cerevisiae.PLoS biology · 2007Article
- Natural meiotic recombination hot spots in the Schizosaccharomyces pombe genome successfully predicted from the simple sequence motif M26.Molecular and cellular biology · 2005Article
- Optimizing the nucleotide sequence of a meiotic recombination hotspot in Schizosaccharomyces pombe.Genetics · 2005Article
- Persistence and loss of meiotic recombination hotspots.Genetics · 2005Article
- Involvement of Sir2/4 in silencing of DNA breakage and recombination on mouse YACs during yeast meiosis.Molecular biology of the cell · 2005Article
- A test of the CoHR motif associated with meiotic double-strand breaks in Saccharomyces cerevisiae.EMBO reports · 2004Article
- Meiotic recombination frequencies are affected by nutritional states in Saccharomycescerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic recombination in yeast is initiated by DNA double-strand breaks (DSBs) that occur at preferred sites, distributed along the chromosomes. These DSB sites undergo changes in chromatin structure early in meiosis, but their common features at the level of DNA sequence have not been defined until now. Alignment of 1 kb sequences flanking six well-mapped DSBs has allowed us to define a flexible sequence motif, the CoHR profile, which predicts the great majority of meiotic DSB locations. The 50 bp profile contains a poly(A) tract in its centre and may have several gaps of unrelated sequences over a total length of up to 250 bp. The major exceptions to the correlation between CoHRs and preferred DSB sites are at telomeric regions, where DSBs do not occur. The CoHR sequence may provide the basis for understanding meiosis-induced chromatin changes that enable DSBs to occur at defined chromosomal sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.