ArticleInfection and immunity2001
Differential gene expression during meningeal-meningococcal interaction: evidence for self-defense and early release of cytokines and chemokines.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Diverse proinflammatory response in pharyngeal epithelial cells upon interaction with Neisseria meningitidis carriage and invasive isolates.BMC infectious diseases · 2024Article
- Interactions and Signal Transduction Pathways Involved during Central Nervous System Entry byInternational journal of molecular sciences · 2020Review
- Detection of Significant Pneumococcal Meningitis Biomarkers by Ego Network.Indian journal of pediatrics · 2017Article
- Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics.Frontiers in pediatrics · 2017Review
- Neisseria meningitidis elicits a pro-inflammatory response involving IκBζ in a human blood-cerebrospinal fluid barrier model.Journal of neuroinflammation · 2014Article
- Anti-inflammatory response following uptake of apoptotic bodies by meningothelial cells.Journal of neuroinflammation · 2014Article
- Deciphering the contribution of human meningothelial cells to the inflammatory and antimicrobial response at the meninges.Infection and immunity · 2013Article
- Infection of Burkholderia cepacia induces homeostatic responses in the host for their prolonged survival: the microarray perspective.PloS one · 2013Article
- Group B Streptococcus interactions with human meningeal cells and astrocytes in vitro.PloS one · 2012Article
- Protocol for gene expression profiling using DNA microarrays in Neisseria gonorrhoeae.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Article
- Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner.Infection and immunity · 2010Article
- Gene expression pattern in human brain endothelial cells in response to Neisseria meningitidis.Infection and immunity · 2007Article
- Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection.Infection and immunity · 2006Article
- Comparison of the inflammatory responses of human meningeal cells following challenge with Neisseria lactamica and with Neisseria meningitidis.Infection and immunity · 2006Article
- Transcriptome analysis of Neisseria meningitidis during infection.Journal of bacteriology · 2003Article
- Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines.Infection and immunity · 2002Article
- Characterization of humoral and cellular immune responses elicited by meningococcal carriage.Infection and immunity · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using microarray technology, we studied the early differential expression of 3,528 genes in human meningothelial cells in response to meningococcal challenge. Thirty-two genes were up-regulated, and four were down-regulated. Those up-regulated included the tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-8 (but not IL-1beta) genes, suggesting that meningeal cells may be a local and early source of these cytokines. Also, a trend in up-regulation of anti-apoptotic genes and down-regulation of pro-apoptotic genes was observed. This is the first evidence that meningothelial cells may mount cytoprotective responses to pathogenic bacteria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.