ArticleInfection and immunity2001
Virulence of a phosphoribosylaminoimidazole carboxylase-deficient Candida albicans strain in an immunosuppressed murine model of systemic candidiasis.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Lethal metabolism of Candida albicans respiratory mutants.PloS one · 2024Article
- Grf10 regulates the response to copper, iron, and phosphate in Candida albicans.G3 (Bethesda, Md.) · 2023Article
- Article
- Identification of Growth Inhibitors of the Fish PathogenFrontiers in microbiology · 2020Article
- Candida albicans Cannot Acquire Sufficient Ethanolamine from the Host To Support Virulence in the Absence ofInfection and immunity · 2018Article
- Purine Acquisition and Synthesis by Human Fungal Pathogens.Microorganisms · 2017Review
- Article
- Comparative genomic analysis reveals a critical role of de novo nucleotide biosynthesis for Saccharomyces cerevisiae virulence.PloS one · 2015Article
- Opportunistic Strains of Saccharomyces cerevisiae: A Potential Risk Sold in Food Products.Frontiers in microbiology · 2015Review
- Modulation of phagosomal pH by Candida albicans promotes hyphal morphogenesis and requires Stp2p, a regulator of amino acid transport.PLoS pathogens · 2014Article
- Comparative transcriptional analysis of clinically relevant heat stress response in Clostridium difficile strain 630.PloS one · 2012Article
- Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus.Acta crystallographica. Section D, Biological crystallography · 2011Article
- Hairpin dsRNA does not trigger RNA interference in Candida albicans cells.Yeast (Chichester, England) · 2011Article
- Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.Nature genetics · 2010Article
- Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening.Bioorganic & medicinal chemistry · 2009Article
- Interrogating the mechanism of a tight binding inhibitor of AIR carboxylase.Bioorganic & medicinal chemistry · 2009Article
- Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.Biochemistry · 2008Article
- Candida albicans uses multiple mechanisms to acquire the essential metabolite inositol during infection.Infection and immunity · 2008Article
- Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus.Eukaryotic cell · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relative pathogenicities of three Candida albicans strains differing in the function of ADE2 (the gene encoding phosphoribosylaminoimidazole carboxylase) were evaluated in a murine candidiasis model. C. albicans strain CAI7 (ade2/ade2), previously constructed by site-specific recombination, was avirulent in immunosuppressed mice compared to the parent strain, CAF2-1, and a heterozygous ADE2/ade2 strain obtained by transforming CAI7 with a wild-type allele. The reduced virulence of CAI7 was correlated with the inability to proliferate in either synthetic medium or serum without the exogenous addition of >10 microg of adenine/ml. The loss of virulence upon site-specific disruption of the ade2 locus, and the restoration of wild-type virulence with the repair of just one ade2 allele, confirmed that the ADE2 gene and de novo purine biosynthesis were required for Candida pathogenicity. The potential of the phosphoribosylaminoimidazole carboxylase enzyme as a novel target for antifungal drug discovery is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.