ArticleInfection and immunity2001
Influence of major histocompatibility complex on bacterial composition of fecal flora.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 181 citations in OpenAlex.
- Trial
- Host immunogenetic variation and gut microbiome functionality in a wild vertebrate population.Microbiome · 2026Article
- Microbiota-Driven Mechanisms in Multiple Sclerosis: Pathogenesis, Therapeutic Strategies, and Biomarker Potential.Biology · 2025Review
- The host genotype actively shapes its microbiome across generations in laboratory mice.Microbiome · 2024Article
- Female reproductive tract microbiota varies with MHC profile.Proceedings. Biological sciences · 2024Article
- Complex Interactions between the Human Major Histocompatibility Complex (MHC) and Microbiota: Their Roles in Disease Pathogenesis and Immune System Regulation.Biomedicines · 2024Review
- Genetic risk score in multiple sclerosis is associated with unique gut microbiome.Scientific reports · 2023Article
- Host gene effects on gut microbiota in type 1 diabetes.Biochemical Society transactions · 2022Review
- Immunogenetic variation shapes the gut microbiome in a natural vertebrate population.Microbiome · 2022Article
- High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites.Frontiers in immunology · 2022Article
- Ruminal background of predisposed milk urea (MU) concentration in Holsteins.Frontiers in microbiology · 2022Article
- Major histocompatibility complex class II genetic diversity and the genetic influence on gut microbiota in Guizhou minipigs.Folia microbiologica · 2021Article
- Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.PLoS pathogens · 2021Article
- Preen gland microbiota covary with major histocompatibility complex genotype in a songbird.Royal Society open science · 2021Article
- Article
- Emerging Concepts in Immune Thrombotic Thrombocytopenic Purpura.Frontiers in immunology · 2021Review
- New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora.Autoimmune diseases · 2021Review
- How MHCII signaling promotes benign host-microbiota interactions.PLoS pathogens · 2020Review
- Bighorn sheep gut microbiomes associate with genetic and spatial structure across a metapopulation.Scientific reports · 2020Article
- The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis.Frontiers in endocrinology · 2020Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Very little is known about how the host genome influences the composition of the gastrointestinal flora, largely due to the great number and diversity of bacteria present in the flora and the difficulties of using traditional methods of bacterial isolation and identification. We have approached the problem by studying bacterium-derived cellular fatty acids in the stool samples of six mouse strains congenic for the major histocompatibility complex (MHC). The results obtained indicate that the composition of the fecal flora is genetically regulated. In addition to undefined gene loci, MHC alone has a pronounced effect, since mice with different MHC in the same background have significantly different fecal floras. Demonstration of the genetic influence on the gastrointestinal flora opens a new approach to studying the pathogenesis of bacterially induced diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.