ArticleInfection and immunity2001
Cellular basis of early cytokine response to Plasmodium falciparum.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
35 citing papers in PubMed, 98 citations in OpenAlex.
- Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans.PLoS pathogens · 2011Trial
- Role of cytokines in immunomodulation during malaria clearance.Annals of medicine and surgery (2012) · 2024Review
- Liposomes for malaria management: the evolution from 1980 to 2020.Malaria journal · 2021Review
- Review
- Article
- T cell-mediated immunity to malaria.Nature reviews. Immunology · 2019Review
- γδ T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance.Frontiers in immunology · 2018Review
- Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea.BMC medicine · 2017Article
- An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection.Journal of visualized experiments : JoVE · 2015Article
- Dysfunctional γδ T cells: a contributing factor for clinical tolerance to malaria?Annals of translational medicine · 2015Article
- γδ T cells and immunity to human malaria in endemic regions.Annals of translational medicine · 2015Article
- Splenic architecture disruption and parasite-induced splenocyte activation and anergy in Plasmodium falciparum-infected Saimiri sciureus monkeys.Malaria journal · 2015Article
- Refrigeration provides a simple means to synchronize in vitro cultures of Plasmodium falciparum.Experimental parasitology · 2014Article
- Cytokine profiles amongst Sudanese patients with visceral leishmaniasis and malaria co-infections.BMC immunology · 2014Article
- Information use and plasticity in the reproductive decisions of malaria parasites.Malaria journal · 2014Article
- Cerebral malaria: gamma-interferon redux.Frontiers in cellular and infection microbiology · 2014Review
- Article
- Letter: chronic non healing wounds and cerebral malaria - for better or for worse?International wound journal · 2012Article
- Severe malarial anemia: innate immunity and pathogenesis.International journal of biological sciences · 2011Review
- Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uncertainty remains about the cellular origins of the earliest phase of the proinflammatory cytokine response to malaria. Here we show by fluorescence-activated cell sorter analysis that gammadelta T cells and CD14+ cells from nonimmune donors produce tumor necrosis factor and that gammadelta T cells also produce gamma interferon within 18 h of contact with mycoplasma-free Plasmodium falciparum-infected erythrocytes in vitro. This early cytokine response is more effectively induced by intact than by lysed parasitized erythrocytes. However, the IFN-gamma response to lysed parasites is considerably enhanced several days after peripheral blood mononuclear cells are primed with low numbers of intact parasitized erythrocytes, and in this case it derives from both alphabeta and gammadelta T cells. These data show that naïve gammadelta T cells can respond very rapidly to malaria infection but that malaria fever may involve a multistage process in which the priming of both gammadelta and alphabeta T-cell populations boosts the cytokine response to lysed parasite products released at schizont rupture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.