ArticleInfection and immunity2001
Immunochemical and biological characterization of three capsular polysaccharides from a single Bacteroides fragilis strain.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Gene regulation inMicrobiology and molecular biology reviews : MMBR · 2025Review
- Commensal bacterial glycosylation at the interface of host-bacteria interactions.Gut microbes · 2025Review
- The Ambivalent Nature ofToxins · 2025Review
- Disruption of Genes Encoding Putative Zwitterionic Capsular Polysaccharides of Diverse Intestinal Bacteroides Reduces the Induction of Host Anti-Inflammatory Factors.Microbial ecology · 2023Article
- Phenotypic and Molecular Characterization of Carbapenem-HeteroresistantAntibiotics (Basel, Switzerland) · 2022Article
- Acceptive Immunity: The Role of Fucosylated Glycans in Human Host-Microbiome Interactions.International journal of molecular sciences · 2021Review
- Strain diversity in the microbiome: Lessons from Bacteroides fragilis.PLoS pathogens · 2020Review
- Synthesis of glycoimmunogen Tn-Thr-PS A1Journal of carbohydrate chemistry · 2020Article
- Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus.Scientific reports · 2016Article
- Carbohydrates as T-cell antigens with implications in health and disease.Glycobiology · 2016Review
- Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.Nature communications · 2015Article
- Infectious and immunologic phenotype of MECP2 duplication syndrome.Journal of clinical immunology · 2015Article
- Protein glycosylation in bacteria: sweeter than ever.Nature reviews. Microbiology · 2010Review
- The modulation of adaptive immune responses by bacterial zwitterionic polysaccharides.International journal of microbiology · 2010Article
- Streptococcus pneumoniae serotype 1 capsular polysaccharide induces CD8CD28 regulatory T lymphocytes by TCR crosslinking.PLoS pathogens · 2009Article
- Oligoclonal CD4+ T cells promote host memory immune responses to Zwitterionic polysaccharide of Streptococcus pneumoniae.Infection and immunity · 2009Article
- Bacteroides: the good, the bad, and the nitty-gritty.Clinical microbiology reviews · 2007Review
- Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation.Infection and immunity · 2005Article
- Characterization of the RokA and HexA broad-substrate-specificity hexokinases from Bacteroides fragilis and their role in hexose and N-acetylglucosamine utilization.Journal of bacteriology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although Bacteroides fragilis accounts for only 0.5% of the normal human colonic flora, it is the anaerobic species most frequently isolated from intra-abdominal and other infections with an intestinal source. The capsular polysaccharides of B. fragilis are part of a complex of surface polysaccharides and are the organism's most important virulence factors in the formation of intra-abdominal abscesses. Two capsular polysaccharides from strain NCTC 9343, PS A1 and PS B1, have been characterized structurally. Their most striking feature is a zwitterionic charge motif consisting of both positively and negatively charged substituent groups on each repeating unit. This zwitterionic motif is essential for abscess formation. In this study, we sought to elucidate structural features of the capsular polysaccharide complex of a commonly studied B. fragilis strain, 638R, that is distinct from strain 9343. We sought a more general picture of the species to establish basic structure-activity and structure-biosynthesis relationships among abscess-inducing polysaccharides. Strain 638R was found to have a capsular polysaccharide complex from which three distinct carbohydrates could be isolated by a complex purification procedure. Compositional and immunochemical studies demonstrated a zwitterionic charge motif common to all of the capsular polysaccharides that correlated with their ability to induce experimental intra-abdominal abscesses. Of interest is the range of net charges of the isolated polysaccharides-from positive (PS C2) to balanced (PS A2) to negative (PS 3). Relationships among structural components of the zwitterionic polysaccharides and their molecular biosynthesis loci were identified.
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