ArticleInfection and immunity2001
Complete nucleotide sequence and analysis of the locus of enterocyte Effacement from rabbit diarrheagenic Escherichia coli RDEC-1.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 98 citations in OpenAlex.
- Protection of rabbits against enteropathogenic Escherichia coli (EPEC) using an intimin null mutant.BMC veterinary research · 2006Trial
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- The RpoE Stress Response Pathway Mediates Reduction of the Virulence of Enteropathogenic Escherichia coli by Zinc.Applied and environmental microbiology · 2015Article
- The role of lymphostatin/EHEC factor for adherence-1 in the pathogenesis of gram negative infection.Toxins · 2010Review
- Development of a live oral attaching and effacing Escherichia coli vaccine candidate using Vibrio cholerae CVD 103-HgR as antigen vector.Microbial pathogenesis · 2010Article
- Feedback effects of host-derived adenosine on enteropathogenic Escherichia coli.FEMS immunology and medical microbiology · 2009Article
- Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1.Infection and immunity · 2009Article
- Article
- Genomic instability in regions adjacent to a highly conserved pch prophage in Escherichia coli O157:H7 generates diversity in expression patterns of the LEE pathogenicity island.Journal of bacteriology · 2009Article
- Systematic identification and sequence analysis of the genomic islands of the enteropathogenic Escherichia coli strain B171-8 by the combined use of whole-genome PCR scanning and fosmid mapping.Journal of bacteriology · 2008Article
- Phylogenetic background of attaching and effacing Escherichia coli isolates from animals.Veterinary research communications · 2008Article
- Protection against Shiga toxin-producing Escherichia coli infection by transcutaneous immunization with Shiga toxin subunit B.Clinical and vaccine immunology : CVI · 2008Article
- The possible influence of LuxS in the in vivo virulence of rabbit enteropathogenic Escherichia coli.Veterinary microbiology · 2007Article
- Pathotyping Escherichia coli by using miniaturized DNA microarrays.Applied and environmental microbiology · 2007Article
- Analysis of the function of enteropathogenic Escherichia coli EspB by random mutagenesis.Infection and immunity · 2006Article
- Protection against hemorrhagic colitis in an animal model by oral immunization with isogeneic rabbit enteropathogenic Escherichia coli attenuated by truncating intimin.Infection and immunity · 2005Article
- Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens.Infection and immunity · 2005Article
- Predominance of afr2 and ral fimbrial genes related to those encoding the K88 and CS31A fimbrial adhesins in enteropathogenic Escherichia coli isolates from rabbits with postweaning diarrhea in Central Europe.Journal of clinical microbiology · 2005Article
- Citrobacter rodentium lifA/efa1 is essential for colonic colonization and crypt cell hyperplasia in vivo.Infection and immunity · 2005Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The pathogenicity island termed the locus of enterocyte effacement (LEE) is found in diverse attaching and effacing pathogens associated with diarrhea in humans and other animal species. To explore the relation of variation in LEE sequences to host specificity and genetic lineage, we determined the nucleotide sequence of the LEE region from a rabbit diarrheagenic Escherichia coli strain RDEC-1 (O15:H-) and compared it with those from human enteropathogenic E. coli (EPEC, O127:H6) and enterohemorrhagic E. coli (EHEC, O157:H7) strains. Differing from EPEC and EHEC LEEs, the RDEC-1 LEE is not inserted at selC and is flanked by an IS2 element and the lifA toxin gene. The RDEC-1 LEE contains a core region of 40 open reading frames, all of which are shared with the LEE of EPEC and EHEC. orf3 and the ERIC (enteric repetitive intergenic consensus) sequence present in the LEEs of EHEC and EPEC are absent from the RDEC-1 LEE. The predicted promoters of LEE1, LEE2, LEE3, tir, and LEE4 operons are highly conserved among the LEEs, although the upstream regions varied considerably for tir and the crucial LEE1 promoter, suggesting differences in regulation. Among the shared genes, high homology (>95% identity) between the RDEC-1 and the EPEC and EHEC LEEs at the predicted amino acid level was observed for the components of the type III secretion apparatus, the Ces chaperones, and the Ler regulator. In contrast, more divergence (66 to 88% identity) was observed in genes encoding proteins involved in host interaction, such as intimin (Eae) and the secreted proteins (Tir and Esps). A comparison of the highly variable genes from RDEC-1 with those from a number of attaching and effacing pathogens infecting different species and of different evolutionary lineages was performed. Although RDEC-1 diverges from some human-infecting EPEC and EHEC, most of the variation observed appeared to be due to evolutionary lineage rather than host specificity. Therefore, much of the observed hypervariability in genes involved in pathogenesis may not represent specific adaptation to different host species.
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