ArticleInfection and immunity2001
Identification of new genes involved in the virulence of Listeria monocytogenes by signature-tagged transposon mutagenesis.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- The Virulence Factor LLO ofFoods (Basel, Switzerland) · 2025Article
- Clinical Findings ofMicroorganisms · 2024Review
- Sugar Modification of Wall Teichoic Acids Determines Serotype-Dependent Strong Biofilm Production in Listeria monocytogenes.Microbiology spectrum · 2022Article
- Pathogenicity and virulence ofVirulence · 2021Article
- A Signature-Tagged Mutagenesis (STM)-based murine-infectivity assay for Cryptococcus neoformans.Journal of microbiology (Seoul, Korea) · 2020Article
- Review
- Article
- Galactosylated wall teichoic acid, but not lipoteichoic acid, retains InlB on the surface of serovar 4b Listeria monocytogenes.Molecular microbiology · 2020Article
- Phage resistance at the cost of virulence: Listeria monocytogenes serovar 4b requires galactosylated teichoic acids for InlB-mediated invasion.PLoS pathogens · 2019Article
- A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates.Nature communications · 2019Article
- Transposon Mutagenesis of Listeria monocytogenes.Methods in molecular biology (Clifton, N.J.) · 2019Article
- The putative amino acid ABC transporter substrate-binding protein AapJ2 is necessary for Brucella virulence at the early stage of infection in a mouse model.Veterinary research · 2018Article
- Discovery of genes required for lipoteichoic acid glycosylation predicts two distinct mechanisms for wall teichoic acid glycosylation.The Journal of biological chemistry · 2018Article
- Article
- InlL fromFrontiers in microbiology · 2017Article
- Analysis of theFrontiers in microbiology · 2017Article
- Use of bacteriophage to target bacterial surface structures required for virulence: a systematic search for antibiotic alternatives.Current genetics · 2016Review
- Comparative Genomics of theFrontiers in microbiology · 2016Article
- L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane.PLoS pathogens · 2015Article
- How Listeria monocytogenes organizes its surface for virulence.Frontiers in cellular and infection microbiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeria monocytogenes is a gram-positive, facultative intracellular pathogen that can cause severe food-born infections in humans and animals. We have adapted signature-tagged transposon mutagenesis to L. monocytogenes to identify new genes involved in virulence in the murine model of infection. We used transposon Tn1545 carried on the integrative vector pAT113. Forty-eight tagged transposons were constructed and used to generate banks of L. monocytogenes mutants. Pools of 48 mutants were assembled, taking one mutant from each bank, injected into mice, and screened for those affected in their multiplication in the brains of infected animals. From 2,000 mutants tested, 18 were attenuated in vivo. The insertions harbored by these mutants led to the identification of 10 distinct loci, 7 of which corresponded to previously unknown genes. The properties of four loci involving putative cell wall components were further studied in vitro and in vivo. The data suggested that these components are involved in bacterial invasion and multiplication in the brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.