ArticleInfection and immunity2001
Differential regulation of Bvg-activated virulence factors plays a role in Bordetella pertussis pathogenicity.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The BvgS PAS Domain, an Independent Sensory Perception Module in theJournal of bacteriology · 2019Article
- Did new transmission cycles in anthropogenic, dense, host populations encourage the emergence and speciation of pathogenic Bordetella?PLoS pathogens · 2019Article
- Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.Medical microbiology and immunology · 2018Review
- Comparison of the Whole Cell Proteome and Secretome of EpidemicFrontiers in microbiology · 2018Article
- The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA.Microbiology (Reading, England) · 2012Review
- Generation and characterization of an attenuated mutant in a response regulator gene of Francisella tularensis live vaccine strain (LVS).DNA and cell biology · 2008Article
- Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis.Journal of bacteriology · 2005Article
- Bordetella bronchiseptica flagellin is a proinflammatory determinant for airway epithelial cells.Infection and immunity · 2005Article
- Role of adhesin release for mucosal colonization by a bacterial pathogen.The Journal of experimental medicine · 2003Article
- Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa.Journal of bacteriology · 2002Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bordetella pertussis, the causative agent of whooping cough, regulates expression of many virulence factors via a two-component signal transduction system encoded by the bvgAS regulatory locus. It has been shown by transcription activation kinetics that several of the virulence factors are differentially regulated. fha is transcribed within 10 min following a bvgAS-inducing signal, while prn is transcribed after 1 h and ptx is not transcribed until 2 to 4 h after induction. These genes therefore represent early, intermediate, and late classes of bvg-activated promoters, respectively. Although there have been many insightful studies into the mechanisms of BvgAS-mediated regulation, the role that differential regulation of virulence genes plays in B. pertussis pathogenicity has not been characterized. We provide evidence that alterations to the promoter regions of bvg-activated genes can alter the kinetic pattern of expression of these genes without changing steady-state transcription levels. In addition, B. pertussis strains containing these promoter alterations that express either ptx at an early time or fha at a late time demonstrate a significant reduction in their ability to colonize respiratory tracts in an intranasal mouse model of infection. These data suggest a role for differential regulation of bvg-activated genes, and therefore for the BvgAS regulatory system, in the pathogenicity of B. pertussis.
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