ArticleMolecular biology reports2000
Characterization of human and mouse H19 regulatory sequences.
Article in Molecular biology reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Introduction to bioimaging-based spatial multi-omic novel methods.Quantitative biology (Beijing, China) · 2023Review
- Increased Expression Level of Long Noncoding RNA H19 in Plasma of Patients with Myocardial Infarction.International journal of molecular and cellular medicine · 2020Article
- High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations.Stem cell reports · 2018Article
- epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data.Genome biology · 2017Article
- Non-coding RNAs in pancreatic cancer: challenges and opportunities for clinical application.Cellular oncology (Dordrecht, Netherlands) · 2016Review
- Fine-mapping cellular QTLs with RASQUAL and ATAC-seq.Nature genetics · 2016Article
- deepBase v2.0: identification, expression, evolution and function of small RNAs, LncRNAs and circular RNAs from deep-sequencing data.Nucleic acids research · 2016Article
- Long Non-coding RNA TUSC7, a Target of miR-23b, Plays Tumor-Suppressing Roles in Human Gliomas.Frontiers in cellular neuroscience · 2016Article
- Article
- miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer.Oncotarget · 2015Article
- Investigation of H19/RsaI Polymorphism in Children With Low Birth Weight in Pernambuco, Brazil.Iranian journal of pediatrics · 2015Article
- Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Down-regulation of achaete-scute complex homolog 1 (ASCL1) in neuroblastoma cells induces up-regulation of insulin-like growth factor 2 (IGF2).Molecular biology reports · 2011Article
- Genomic identification of regulatory elements by evolutionary sequence comparison and functional analysis.Advances in genetics · 2008Review
- Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
H19 is expressed in a large percentage of bladder tumors, but not expressed in healthy bladder tissue. The aim of this study is to define H19 optimal transcriptional regulatory sequences in tumor cells, which can potentially be used to control expression of a toxin gene in constructs to be used in bladder cancer gene therapy trials in mice and human. Transient expression assays revealed that elements responsible for promoter activity are contained within the 85 bp upstream region. The transcriptional activity of this region was strongly inhibited by the methylation of the Hpa II sites. A modest cell specificity is conferred by the upstream sequences. The human and murine promoter activities were significantly increased by the human H19 4.1 kb enhancer sequence. The 85 bp H19 upstream region contains all the elements to interact with the enhancer. We showed that the human H19 promoter is highly active in a murine bladder carcinoma cell line, justifying its use to drive the expression of a cytotoxin gene in gene therapy trials in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.