ArticleThe Plant cell2001
Many parallel losses of infA from chloroplast DNA during angiosperm evolution with multiple independent transfers to the nucleus.
Article in The Plant cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 282 papers.
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Who cites it
282 citing papers in PubMed, 532 citations in OpenAlex.
- Comparative plastome analysis and plastomic phylogeny of Moraceae with expanded species-level sampling.BMC plant biology · 2026Article
- Characterization and comparative analysis of the complete chloroplast genomes of twelve Allium species from Kazakhstan.Scientific reports · 2026Article
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- Plastid genomes and phylogenomic relationships in Cheilosoideae, a poorly known early-diverging subfamily of Euphorbiaceae.BMC plant biology · 2026Article
- Comprehensive analysis of the complete chloroplast genome of white pomegranate and phylogenetic relationships within Myrtales.BMC genomics · 2026Article
- Chloroplast genome sequencing in winged bean (Psophocarpus tetragonolobus L.) and comparative analysis with other legumes.BMC plant biology · 2026Article
- Chloroplast genomes of nineFrontiers in plant science · 2026Article
- The complete chloroplast genome and phylogenetic analysis ofMitochondrial DNA. Part B, Resources · 2026Article
- Comparative chloroplast genome analysis of fourFrontiers in plant science · 2026Article
- The complete chloroplast genome sequence and phylogenetic analysis of an invasive plantMitochondrial DNA. Part B, Resources · 2026Article
- Plastome evidence repositionsFrontiers in plant science · 2026Article
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- Comparative and phylogenetic analyses based on the complete chloroplast genomes of Limonium (Plumbaginaceae) species.BMC plant biology · 2025Article
- Comparative analysis of butternut (Juglans cinerea) and Japanese walnut (Juglans ailantifolia) chloroplast genomes.BMC plant biology · 2025Article
- Chloroplast Genome Characterization ofEcology and evolution · 2025Article
- A Comprehensive Comparative Analysis and Phylogenetic Investigation of the Chloroplast Genome Sequences in FourCurrent issues in molecular biology · 2025Article
- PCR-Based Molecular Authentication Method for Sources of Agrimoniae Herba via Comparative Analyses of Complete Chloroplast Genomes.International journal of molecular sciences · 2025Article
- Phylogenomic Analyses and DNA Barcoding Development Within Moraceae: Insights Into Genomic Features, Mutational Hotspots, and Adaptive Evolution.Ecology and evolution · 2025Article
- Insights into the plastome evolution and phylogenetic relationships of Lepidium (Brassicaceae).BMC plant biology · 2025Article
222 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 8 institutions in 4 countries.
Funding
Abstract
We used DNA sequencing and gel blot surveys to assess the integrity of the chloroplast gene infA, which codes for translation initiation factor 1, in >300 diverse angiosperms. Whereas most angiosperms appear to contain an intact chloroplast infA gene, the gene has repeatedly become defunct in approximately 24 separate lineages of angiosperms, including almost all rosid species. In four species in which chloroplast infA is defunct, transferred and expressed copies of the gene were found in the nucleus, complete with putative chloroplast transit peptide sequences. The transit peptide sequences of the nuclear infA genes from soybean and Arabidopsis were shown to be functional by their ability to target green fluorescent protein to chloroplasts in vivo. Phylogenetic analysis of infA sequences and assessment of transit peptide homology indicate that the four nuclear infA genes are probably derived from four independent gene transfers from chloroplast to nuclear DNA during angiosperm evolution. Considering this and the many separate losses of infA from chloroplast DNA, the gene has probably been transferred many more times, making infA by far the most mobile chloroplast gene known in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.