ArticleThe Plant cell2001
HC-Pro suppression of transgene silencing eliminates the small RNAs but not transgene methylation or the mobile signal.
Article in The Plant cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed, 302 citations in OpenAlex.
- Potato Virus Y NIb Multifunctional Protein Suppresses Antiviral Defense by Interacting with Several Protein Components of the RNA Silencing Pathway.International journal of molecular sciences · 2026Article
- Truncated CMV2bPlant methods · 2025Article
- Structural features of T-DNA that induce transcriptional gene silencing during agroinfiltration.Plant biotechnology (Tokyo, Japan) · 2023Article
- Long distance signalling and epigenetic changes in crop grafting.Frontiers in plant science · 2023Review
- Suppressors of RNA silencing encoded by geminiviruses and associated DNA satellites.Virusdisease · 2019Article
- Development of a new tobamovirus-based viral vector for protein expression in plants.Molecular biology reports · 2019Article
- Mini review: Revisiting mobile RNA silencing in plants.Plant science : an international journal of experimental plant biology · 2019Review
- A Genetic Network for Systemic RNA Silencing in Plants.Plant physiology · 2018Article
- A Violaxanthin Deepoxidase Interacts with a Viral Suppressor of RNA Silencing to Inhibit Virus Amplification.Plant physiology · 2017Article
- Arabidopsis CML38, a Calcium Sensor That Localizes to Ribonucleoprotein Complexes under Hypoxia Stress.Plant physiology · 2016Article
- P2 of Rice grassy stunt virus (RGSV) and p6 and p9 of Rice ragged stunt virus (RRSV) isolates from Vietnam exert suppressor activity on the RNA silencing pathway.Virus genes · 2015Article
- BnSGS3 Has Differential Effects on the Accumulation of CMV, ORMV and TuMV in Oilseed Rape.Viruses · 2015Article
- Nucleotide sequence-homology-independent breakdown of transgenic resistance by more virulent virus strains and a potential solution.Scientific reports · 2015Article
- Induction of resistance to potato virus Y strain NTN in potato plants through RNAi.Biotechnology, biotechnological equipment · 2015Article
- Systematic phenotypic screen of Arabidopsis peroxisomal mutants identifies proteins involved in β-oxidation.Plant physiology · 2014Article
- Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Proteome analysis of peroxisomes from etiolated Arabidopsis seedlings identifies a peroxisomal protease involved in β-oxidation and development.Plant physiology · 2013Article
- Enhanced transgene expression in sugarcane by co-expression of virus-encoded RNA silencing suppressors.PloS one · 2013Article
- Comparative analysis of RNA silencing suppression activities between viral suppressors and an endogenous plant RNA-dependent RNA polymerase.Virus genes · 2012Article
- HC-Pro silencing suppressor significantly alters the gene expression profile in tobacco leaves and flowers.BMC plant biology · 2011Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-transcriptional gene silencing (PTGS) is a sequence-specific RNA degradation mechanism that is widespread in eukaryotic organisms. It is often associated with methylation of the transcribed region of the silenced gene and with accumulation of small RNAs (21 to 25 nucleotides) homologous to the silenced gene. In plants, PTGS can be triggered locally and then spread throughout the organism via a mobile signal that can cross a graft junction. Previously, we showed that the helper component-proteinase (HC-Pro) of plant potyviruses suppresses PTGS. Here, we report that plants in which PTGS has been suppressed by HC-Pro fail to accumulate the small RNAs associated with silencing. However, the transgene locus of these plants remains methylated. Grafting experiments indicate that HC-Pro prevents the plant from responding to the mobile silencing signal but does not eliminate its ability to produce or send the signal. These results demonstrate that HC-Pro functions downstream of transgene methylation and the mobile signal at a step preceding accumulation of the small RNAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.