ArticleThe Journal of physiology2001
Glycogen synthase localization and activity in rat skeletal muscle is strongly dependent on glycogen content.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 136 citations in OpenAlex.
- Coffee Increases Post-Exercise Muscle Glycogen Recovery in Endurance Athletes: A Randomized Clinical Trial.Nutrients · 2021Trial
- Large pre- and postexercise rapid-acting insulin reductions preserve glycemia and prevent early- but not late-onset hypoglycemia in patients with type 1 diabetes.Diabetes care · 2013Trial
- Effect of acute exercise on glucose tolerance following post-exercise feeding.European journal of applied physiology · 2007Trial
- Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans.The Journal of physiology · 2005Trial
- Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes.The Journal of physiology · 2002Trial
- Skeletal Muscle Consequences of Phosphatidylethanolamine Synthesis Deficiency.Function (Oxford, England) · 2023Article
- Anti-diabetic effects of linarin fromChinese herbal medicines · 2022Article
- Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future.Advances in neurobiology · 2019Review
- The 3T3-L1 adipocyte glycogen proteome.Proteome science · 2013Article
- Skeletal muscle glycogen content and particle size of distinct subcellular localizations in the recovery period after a high-level soccer match.European journal of applied physiology · 2012Article
- Increased laforin and laforin binding to glycogen underlie Lafora body formation in malin-deficient Lafora disease.The Journal of biological chemistry · 2012Article
- Article
- Regulation of glucose and glycogen metabolism during and after exercise.The Journal of physiology · 2012Review
- Glycogen accumulation in cardiomyocytes and cardiotoxic effects after 3NPA treatment.Bosnian journal of basic medical sciences · 2012Article
- Brain glycogen-new perspectives on its metabolic function and regulation at the subcellular level.Frontiers in neuroenergetics · 2012Article
- Hexokinase 2, glycogen synthase and phosphorylase play a key role in muscle glycogen supercompensation.PloS one · 2012Article
- Differential pattern of glycogen accumulation after protein phosphatase 1 glycogen-targeting subunit PPP1R6 overexpression, compared to PPP1R3C and PPP1R3A, in skeletal muscle cells.BMC biochemistry · 2011Article
- Article
- Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization.The Journal of biological chemistry · 2009Article
- The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor.Cell metabolism · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
1. The influence of muscle glycogen content on glycogen synthase (GS) localization and GS activity was investigated in skeletal muscle from male Wistar rats. 2. Two groups of rats were obtained, preconditioned with a combination of exercise and diet to obtain either high (HG) or low (LG) muscle glycogen content. The cellular distribution of GS was studied using subcellular fractionation and confocal microscopy of immunostained single muscle fibres. Stimulation of GS activity in HG and LG muscle was obtained with insulin or contractions in the perfused rat hindlimb model. 3. We demonstrate that GS translocates from a glycogen-enriched membrane fraction to a cytoskeleton fraction when glycogen levels are decreased. Confocal microscopy supports the biochemical observations that the subcellular localization of GS is influenced by muscle glycogen content. GS was not found in the nucleus. 4. Investigation of the effect of glycogen content on GS activity in basal and insulin- and contraction-stimulated muscle shows that glycogen has a strong inhibitory effect on GS activity. Our data demonstrate that glycogen is a more potent regulator of glycogen synthase activity than insulin. Furthermore we show that the contraction-induced increase in GS activity is merely a result of a decrease in muscle glycogen content. 5. In conclusion, the present study shows that GS localization is influenced by muscle glycogen content and that not only basal but also insulin- and contraction-stimulated GS activity is strongly regulated by glycogen content in skeletal muscle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.