ArticleThe EMBO journal2001
Non-templated addition of nucleotides to the 3' end of nascent RNA during RNA editing in Physarum.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Molecular insight into 5' RNA capping with NpNature chemical biology · 2026Article
- Genetic Diversity in the mtDNA ofGenes · 2023Review
- A specific, promoter-independent activity of T7 RNA polymerase suggests a general model for DNA/RNA editing in single subunit RNA Polymerases.Scientific reports · 2018Article
- Mitochondrial Genome Evolution and a Novel RNA Editing System in Deep-Branching Heteroloboseids.Genome biology and evolution · 2017Article
- Article
- Novel modes of RNA editing in mitochondria.Nucleic acids research · 2016Article
- SCOPE++: sequence classification of homoPolymer emissions.Genomics · 2014Article
- Darned in 2013: inclusion of model organisms and linking with Wikipedia.Nucleic acids research · 2013Article
- Complete characterization of the edited transcriptome of the mitochondrion of Physarum polycephalum using deep sequencing of RNA.Nucleic acids research · 2011Article
- When you can't trust the DNA: RNA editing changes transcript sequences.Cellular and molecular life sciences : CMLS · 2011Review
- Two forms of RNA editing are required for tRNA maturation in Physarum mitochondria.RNA (New York, N.Y.) · 2010Article
- Distinct roles for sequences upstream of and downstream from Physarum editing sites.RNA (New York, N.Y.) · 2009Article
- Non-DNA-templated addition of nucleotides to the 3' end of RNAs by the mitochondrial RNA polymerase of Physarum polycephalum.Molecular and cellular biology · 2008Article
- Identification of a putative mitochondrial RNA polymerase from Physarum polycephalum: characterization, expression, purification, and transcription in vitro.Current genetics · 2006Article
- Discovery of new genes and deletion editing in Physarum mitochondria enabled by a novel algorithm for finding edited mRNAs.Nucleic acids research · 2005Article
- Unexpectedly complex editing patterns at dinucleotide insertion sites in Physarum mitochondria.Molecular and cellular biology · 2004Article
- Editing site recognition and nucleotide insertion are separable processes in Physarum mitochondria.The EMBO journal · 2002Article
- Cotranscriptional editing of Physarum mitochondrial RNA requires local features of the native template.RNA (New York, N.Y.) · 2002Article
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Authors and funding
3 authors.
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Abstract
RNAs in Physarum: mitochondria contain extra nucleotides that are not encoded by the mitochondrial genome, at least in the traditional sense. While it is known that insertion of non-encoded nucleotides is linked to RNA synthesis, the exact nature of this relationship remains unclear. Here we demonstrate that the efficiency of editing is sensitive not only to the concentration of the nucleotide that is inserted, but also to the concentration of the nucleotide templated just downstream of an editing site. These data strongly support a co-transcriptional mechanism of Physarum: RNA editing in which non-encoded nucleotides are added to the 3' end of nascent RNAs. These results also suggest that transcription elongation and nucleotide insertion are competing processes and that recognition of editing sites most likely involves transient pausing by the Physarum: mitochondrial RNA polymerase. In addition, the pattern of nucleotide concentration effects, the context of editing sites and the accuracy of the mitochondrial RNA polymerase argue that the mechanism of Physarum: editing is distinct from that of other co-transcriptional editing systems.
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