ArticleBritish journal of pharmacology2001
Nerve evoked P2X receptor contractions of rat mesenteric arteries; dependence on vessel size and lack of role of L-type calcium channels and calcium induced calcium release.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 77 citations in OpenAlex.
- Purinoceptor: a novel target for hypertension.Purinergic signalling · 2023Review
- Purinergic receptor antagonism: A viable strategy for the management of autonomic dysreflexia?Autonomic neuroscience : basic & clinical · 2021Article
- Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells.Frontiers in endocrinology · 2020Review
- The crosstalk between autonomic nervous system and blood vessels.International journal of physiology, pathophysiology and pharmacology · 2018Review
- Imaging sympathetic neurogenic CaAutonomic neuroscience : basic & clinical · 2017Review
- From one generation to the next: a comprehensive account of sympathetic receptor control in branching arteriolar trees.The Journal of physiology · 2015Article
- Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed.Purinergic signalling · 2014Article
- Perivascular innervation: a multiplicity of roles in vasomotor control and myoendothelial signaling.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Antioxidant treatment restores prejunctional regulation of purinergic transmission in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats.Neuroscience · 2010Article
- The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation.British journal of pharmacology · 2010Article
- Alterations in sympathetic neuroeffector transmission to mesenteric arteries but not veins in DOCA-salt hypertension.Autonomic neuroscience : basic & clinical · 2010Article
- NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse.Cardiovascular research · 2010Article
- Nerve-evoked purinergic signalling suppresses action potentials, Ca2+ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle.The Journal of physiology · 2009Article
- Sympathetic neurogenic Ca2+ signalling in rat arteries: ATP, noradrenaline and neuropeptide Y.Experimental physiology · 2009Article
- Purinergic receptors in the splanchnic circulation.Purinergic signalling · 2008Article
- Noradrenergic vasoconstriction of pig prostatic small arteries.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- Differences in sympathetic neuroeffector transmission to rat mesenteric arteries and veins as probed by in vitro continuous amperometry and video imaging.The Journal of physiology · 2007Article
- Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed.British journal of pharmacology · 2007Article
- Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis.The Journal of physiology · 2007Article
- ATP is the predominant sympathetic neurotransmitter in rat mesenteric arteries at high pressure.The Journal of physiology · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Contractile responses to short trains of nerve stimulation have been characterized in small, medium and large arteries from the rat mesenteric circulation (5th - 6th, 2nd - 3rd and 1st order, respectively). In addition, sources of calcium for smooth muscle contraction have been investigated. 2. Nerve stimulation (10 pulses at 10 Hz) evoked reproducible contractions. The P2 receptor antagonist suramin (100 microM) reduced constrictions by 65.3+/-7.4, 82.7+/-3.3 and 3.1+/-6.1% in small, medium and large arteries respectively. The alpha-adrenoceptor antagonist prazosin (0.1 microM) reduced responses by 32.6+/-2.6, 27.0+/-1.5 and 97.0+/-1.9% respectively. 3. The L-type calcium channel antagonist nifedipine (1 microM) reduced nerve-evoked contractions by 2.8+/-3.3, 10.0+/-3.7 and 13.5+/-2.7% in small, medium and large arteries respectively. When the adrenergic component of contraction was blocked by prazosin (0.1 microM) nifedipine reduced responses by 4.6+/-7.9, 14.3+/-2.0 and 3.0+/-1.9% respectively. Contractile responses to exogenous alpha,beta-meATP were unaffected by the depletion of calcium stores with cyclopiazonic acid (30 microM). This indicates that mobilization of calcium from internal stores is not required for P2X receptor mediated smooth muscle contraction. We conclude that for neurogenic responses, the P2X receptor mediated component of constriction dominates in small mesenteric arteries (3rd -- 6th order) while in large arteries (1st order) noradrenaline mediates contraction. For P2X receptor mediated responses all the calcium required for smooth muscle contraction enters the cell directly through P2X receptor channels.
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